360 Pages 229 Color Illustrations
    by CRC Press

    Basic Clinical Radiobiology is a concise but comprehensive textbook setting out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics, and radiation technology.

    Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, this fifth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.

    This new edition is highly illustrated with attractive 2-colour presentation and now includes new chapters on stem cells, tissue response and the convergence of radiotherapy, radiobiology, and physics. It will be invaluable for FRCR (clinical oncology) and equivalent candidates, SpRs (and equivalent) in radiation oncology, practicing radiation oncologists and radiotherapists, as well as radiobiologists and radiotherapy physicists.

    Preface

    Contributors

    1. Introduction: The significance of radiobiology and radiotherapy for cancer treatment

    Michael C. Joiner, Albert J. van der Kogel and G. Gordon Steel

    2. Irradiation-induced damage and the DNA damage response

    Conchita Vens, Marianne Koritzinsky and Bradly G. Wouters

    3. Cell death after irradiation: How, when and why cells die

    Bradly G. Wouters

    4. Quantifying cell kill and cell survival

    Michael C. Joiner

    5. Radiation dose-response relationships

    Søren M. Bentzen

    6. Linear energy transfer and relative biological effectiveness

    Michael C. Joiner, Jay W. Burmeister and Wolfgang Dörr

    7. Physics of radiation therapy for the radiobiologist

    Jay W. Burmeister and Michael C. Joiner

    8. Tumour growth and response to radiation

    Daniel Zips

    9. Fractionation: The linear-quadratic approach

    Michael C. Joiner and Søren M. Bentzen

    10. The linear-quadratic approach in clinical practice

    Søren M. Bentzen and Michael C. Joiner

    11. Modified fractionation

    Michael Baumann, Mechthild Krause and Vincent Grégoire

    12. Time factors in normal tissue responses to irradiation

    Wolfgang Dörr

    13. The dose-rate effect

    Albert J. van der Kogel and Michael C. Joiner

    14. Pathogenesis of normal tissue side effects

    Wolfgang Dörr

    15. Stem cells in radiotherapy

    Robert P. Coppes, Michael Baumann, Mechthild Krause and Richard P. Hill

    16. Normal tissue tolerance and the effect of dose inhomogeneities

    Wolfgang Dörr and Albert J. van der Kogel

    17. The oxygen effect and therapeutic approaches to tumour hypoxia

    Michael R. Horsman, J. Martin Brown, Albert J. van der Kogel, Bradly G. Wouters and Jens Overgaard

    18. The tumour microenvironment and cellular hypoxia responses

    Bradly G. Wouters, Marianne Koritzinsky, J. Martin Brown and Albert J. van der Kogel

    19. Combined radiotherapy and chemotherapy

    Vincent Grégoire, Jean-Pascal Machiels and Michael Baumann

    20. Molecular targeted agents for enhancing tumour response

    Michael Baumann, Mechthild Krause and Vincent Grégoire

    21. Biological individualisation of radiotherapy

    Catharine M.L. West, Robert G. Bristow and Adrian C. Begg

    22. Molecular image guided radiotherapy

    Vincent Grégoire, Karin Haustermans and John Lee

    23. Retreatment tolerance of normal tissues

    Wolfgang Dörr, Dorota Gabryś and Fiona A. Stewart

    24. Biological response modification of normal tissue reactions: Basic principles and pitfalls

    Wolfgang Dörr

    25. Hadron therapy: The clinical aspects

    Vincent Grégoire, Jay W. Burmeister, Michael C. Joiner and Wolfgang Dörr

    26. Tissue response models

    Peter van Luijk, Wolfgang Dörr and Albert J. van der Kogel

    27. Second cancers after radiotherapy

    Klaus Rüdiger Trott and Wolfgang Dörr

    Glossary

    Index

    Biography

    Michael Joiner: Professor of Radiobiology, Wayne State University, USA

    Albert van der Kogel: Emeritus Professor of Radiobiology, Radboud University Nijmegen Medical Centre, The Netherlands; also Department of Human Oncology, University of Wisconsin, USA

    "...a valuable resource for more clinically minded individuals needing to know the basics of tissue and tumor response to a variety of radiation regimens."

    Robert J Griffin, PhD (University of Arkansas for Medical Sciences)