1st Edition
The Kinesin Superfamily Handbook Transporter, Creator, Destroyer
This book brings together current information on the families that make up the kinesin superfamily of molecular motors in one comprehensive text; an ideal reference for researchers looking to make comparisons between different families, for specific information on an individual family, or simply for an overview of the kinesin superfamily.
Information is clearly structured and grouped according to individual families and organised in a standardised way, allowing the reader to easily search and retrieve information on this large superfamily of molecular motors and understand how its individual members carry out a diverse variety of cellular functions.
Features:
- The first book dedicated to the entire kinesin superfamily
- Enables a fuller understanding of this family of proteins, which is becoming an increasing focus of research due to its involvement in diseases such as cancer, neuropathies and ciliopathies
- Written in a manner accessible to a range of researchers in the life and medical sciences, including biophysicists, biochemists and medical researchers.
Chapter 4 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.here.
Chapter 11 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.here.
Contents
Acknowledgements....................................................................................................ix
Editor bio...................................................................................................................xi
List of Contributors................................................................................................. xiii
Chapter 1 Introduction to the Kinesin Superfamily..............................................1
Hannah R. Belsham and Claire T. Friel
Chapter 2 The Kinesin-1 Family: Long-Range Transporters.............................. 15
David D. Hackney and Alison E. Twelvetrees
Chapter 3 The Kinesin-2 Family: Transporters................................................... 33
William O. Hancock
Chapter 4 The Kinesin-3 Family: Long-Distance Transporters.......................... 41
Nida Siddiqui and Anne Straube
Chapter 5 The Kinesin-4 Family......................................................................... 55
Claire T. Friel
Chapter 6 The Kinesin-5 Family: Transporters and Creators.............................65
Mary Popov, Alina Goldstein-Levitin and Larisa Gheber
Chapter 7 The Kinesin-6 Family.........................................................................83
Claire T. Friel
Chapter 8 The Kinesin-8 Family.........................................................................87
Tianyang Liu, Alejandro Peña, Fiona Shilliday, and
Carolyn A. Moores
Chapter 9 The Kinesin-13 Family: Specialist Destroyers.................................. 101
Julie P. Welburn and Claire T. Friel
Chapter 10 The Kinesin-14 Family...................................................................... 115
Marcus Braun, Stefan Diez and Zdenek Lansky
Chapter 11 The Kinesin-15 Family...................................................................... 135
Hauke Drechsler, Jaspreet Singh Grewal and Andrew D. McAinsh
Chapter 12 The Kinesin-16 Family...................................................................... 155
Hanan M. Alghamdi and Claire T. Friel
Chapter 13 Other Kinesin Families..................................................................... 161
Claire T. Friel
Chapter 14 Summary and Future Perspectives.................................................... 165
Claire T. Friel
Index....................................................................................................................... 167
Biography
Claire T. Friel earned a BSc in Biochemistry from the University of Glasgow, UK, and carried out her PhD work on protein folding kinetics in the laboratory of Sheena Radford at the University of Leeds, UK. In 2006, she joined the group of Jonathon Howard at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany. There, she solved the ATP turnover cycle of the microtubule depolymerising Kinesin-13, MCAK, and developed an interest in the kinesin superfamily of molecular motors. Since 2011, Claire has held the position of Assistant Professor at the University of Nottingham, UK. The research goals of the Friel lab are to understand the relationship between the kinesin motor domain sequence and the many functional properties of the kinesin superfamily and to understand the molecular mechanisms of proteins that regulate microtubule dynamics.
"Friel (Univ. of Nottingham) has edited and produced, along with some 19 other expert contributors, a concise reference on kinesins, an important class of proteins that generate force and displacement along cellular microtubules in a wide range of cell types and organisms. The book is organized by sequencing the chapters in the same way as the superfamily itself is organized, such that each covers a different kinesin family, and one chapter is devoted collectively to those families not otherwise covered.
Chapters are formatted consistently, allowing for easy cross-reading to obtain an overview of functional and physiological roles. Each chapter ends with a discussion of the subject kinesin family's involvement in various diseases. Chapters are thoroughly referenced with citations to original literature. This compilation from a wide range of kinesin authorities would be useful to undergraduates working on research projects, as well as to researchers in the field. Recommended. Upper-division undergraduates. Graduate students, faculty, and professionals"-J. A. Kelly, emerita, University of Connecticut in CHOICE, September 2021 Vol. 59 No. 1
