4th Edition
Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine
Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine 4E has been fully updated and revised. The clinical diagnostic approach to common infectious disease problems in the CCU is the underlying theme in the book. Emphasized throughout is the importance of formulating an accurate early presumptive clinical syndromic diagnosis which is the basis for selecting optimal initial antimicrobial therapy in the CCU. Without an accurate presumptive clinical diagnosis, effective therapy is unlikely at best. Based on the most probable clinical diagnosis, optimal antibiotic empiric therapy, based on antimicrobial stewardship principles, minimizes resistance and antibiotic complications in the CCU.
This new edition features chapters that explain the tenets of differential diagnostic reasoning, differential diagnostic characteristics of fever patterns in the CCU. The proper interpretation of rapid diagnostic tests, in the appropriate clinical context, is included. The diagnostic importance of cardinal clinical findings, particularly when combined, in the appropriate clinical context is emphasized and remains the basis for clinical problem solving in the CCU. Uniquely, critical diagnostic physical findings in the CCU, including color atlas of diagnostic eye findings, are included as important diagnostic determinants in the CCU.
Written by infectious disease clinicians for CCU consultants, Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine 4E remains a useful evidence based and experience tempered key clinical resource for infectious disease problems in the CCU.
Key Features
- Essentials of the tenets of clinical diagnostic reasoning is explained as it relates to formulating a rapid and accurate clinical syndromic diagnosis in the CCU
- The diagnostic significance of fever patterns and their relationship to the pulse rate in the proper clinical context is explained in depth as related to the CCU setting
- Formulating an accurate early clinical syndromic diagnosis is presented as essential since it is the basis of effective empiric antibiotic therapy in the CCU
- How to combine key non-specific laboratory and imaging findings to increase diagnostic specificity and diagnostic probability in the CCU is presented
- Clinical perspective on the proper interpretation of the clinical significance of rapid diagnostic test results in the CCU is included
- A clinical approach to apparent "antibiotic failure" in the CCU is presented either due to actual antibiotic failure or seeming but unrelated non-antibiotic failure
- Section focuses on the practical aspects of antimicrobial stewardship particularly as related to optimizing dosing effectiveness while minimizing resistance and adverse effects in the CCU
Foreword
Preface to the First Edition
Preface to the Second Edition
Preface to the Third Edition
Preface to the Fourth Edition
Editors
Contributors
SECTION I: CLINICAL DIAGNOSTIC APPROACH IN THE CRITICAL CARE UNIT
1. Diagnostic Reasoning and Clinical Problem Solving
Burke A. Cunha
2. Clinical Approach to Fever in the Critical Care Unit
Burke A. Cunha
3. Physical Exam Clues and Their Mimics in Infectious Diseases in the Critical Care Unit
Yehia Y. Mishriki
4. Ophthalmologic Clues to Infectious Diseases and Their Mimics in the Critical Care Unit
Cheston B. Cunha, Michael J. Wilkinson, and David A. Quillen
5. Radiology of Infectious Diseases and Their Potential Mimics in the Critical Care Unit
Jocelyn A. Luongo, Boris Shapiro, Orlando A. Ortiz, and Douglas S. Katz
6. Non-specific Laboratory Tests in the Critical Care Unit
Charles W. Stratton
7. Infections and Their Mimics in Returning Travelers in the Critical Care Unit
Elise Kochoumian, Jonathon Moore, Bushra Mina, and Kevin Cahill
8. Diagnostic Approach to Rash and Fever in the Critical Care Unit
Lee S. Engel, Charles V. Sanders, and Fred A. Lopez
9. Severe Tick-Borne Infections and Their Mimics in the Critical Care Unit
Praveen Sudhindra and Gary P. Wormser
SECTION II: CLINICAL SYNDROMIC APPROACH IN THE CRITICAL CARE UNIT
10. The Clinical Approach to Sepsis and Its Mimics in the Critical Care Unit
Abdullah Chahin and Steven M. Opal
11. Acute Bacterial Meningitis and Its Mimics in the Critical Care Unit
Burke A. Cunha
12. Encephalitis and Its Mimics in the Critical Care Unit
John J. Halperin
13. Severe Community-Acquired Pneumonia in the Critical Care Unit
Burke A. Cunha
14. Legionnaire’s Disease and Severe Pneumonia Mimics in the Critical Care Unit
Burke A. Cunha
15. Severe Influenza Pneumonia and Its Mimics in the Critical Care Unit
Eleni E. Magira
16. Severe Non-influenza Viral Pneumonia in the Critical Care Unit
David Waldner, Thomas J. Marrie, and Wendy Sligl
17. Nosocomial Pneumonia in the Critical Care Unit
Burke A. Cunha
18. Central Venous Catheter Infection in the Critical Care Unit
Emilio Bouza and Almudena Burillo
19. Acute Infective Endocarditis and Its Mimics in the Critical Care Unit
John L. Brusch
20. Diagnostic Approach to Myocarditis in the Critical Care Unit
Shabnam Seydafkan and Jason M. Lazar
21. Intra-Abdominal Surgical Infections and Their Mimics in the Critical Care Unit
Donald E. Fry
22. Clostridium difficile and Its Mimics in the Critical Care Unit
Burke A. Cunha
23. Diagnostic Approach to Fulminant Hepatitis in the Critical Care Unit
Huei-Wen Lim and David Bernstein
24. Diagnostic Approach to Acute Kidney Injury in the Critical Care Unit
Sonali Gupta, Divyansh Bajaj, Sana Idrees, and Joseph Mattana
SECTION III: CLINICAL APPROACH TO INFECTIONS IN COMPROMISED HOSTS IN THE CRITICAL CARE UNIT
25. Overwhelming Post-Splenectomy Infections in the Critical Care Unit
Larry I. Lutwick and Jana Preis
26. Infections in Cirrhosis in the Critical Care Unit
John M. Horne and Laurel C. Preheim
27. Febrile Neutropenia in the Critical Care Unit
Perrine Parize, Anne Pouvaret, Paul-Louis Woerther, Frédéric Pène, and Olivier Lortholary
28. Infections Related to Steroids and Immunosuppressive Agents in the Critical Care Unit
Gülden Yilmaz and Müge Ayhan
29. Infections in Solid Organ Transplant Recipients Admitted to the Critical Care Unit
Almudena Burillo, Patricia Muñoz, and Emilio Bouza
30. Care of Critically Ill Patients with HIV
Joseph Metmowlee Garland, Andrew Levinson, and Edward Wing
SECTION IV: ANTIMICROBIAL THERAPY AND ANTIBIOTIC STEWARDSHIP IN THE CRITICAL CARE UNIT
31. Principles of Antibiotic Stewardship in the Critical Care Unit
Cheston B. Cunha
32. Colonization, Infection, and Resistance in the Critical Care Unit
Edward J. Septimus
33. Rapid Infectious Diseases Diagnostics in the Critical Care Unit
Bronwen Garner and Kimberly Hanson
34. Antibiotic Therapy of Multidrug Resistant Organisms in the Critical Care Unit
Burke A. Cunha
35. Antibiotic Therapy in the Penicillin-Allergic Patient in the Critical Care Unit
Burke A. Cunha
36. Adverse Reactions to Antibiotics in the Critical Care Unit
Diane M. Parente, Cheston B. Cunha, and Michael Lorenzo
37. Antibiotic Dosage Adjustment in Renal Insufficiency and Hemodialysis in the Critical Care Unit
Damary C. Torres, Kristina Bruno, and Danielle Maffei
38. Antibiotic Failure: Apparent or Actual in the Critical Care Unit
Burke A. Cunha
Index
Biography
Cheston B. Cunha, MD, FACP is Medical Director of the Antimicrobial Stewardship Program at Rhode Island Hospital and The Miriam Hospital in Providence, Rhode Island, USA. He is also an attending in adult infectious disease in the Division of Infectious Diseases is Assistant Professor of Medicine at Brown University Alpert School of Medicine. Dr. Cunha has written/co-written 51 articles, 53 book chapters and 7 books. He has been an Editor of Antibiotic Stewardship, Antibiotic Essentials (15th, 16th Edition), Clinical Infectious Diseases (3rd Edition), and Infectious Diseases in Critical Care Medicine and Antibiotic Stewardship (4th Edition). He has been an annual recipient of the Dean’s Excellence in Teaching Award from the Alpert Medical School of Brown University.
Burke A. Cunha, MD, MACP is Chief, Infectious Disease Division at NYU Winthrop Hospital, Mineola, New York and Professor of Medicine, State University of New York School of Medicine, Stony Brook, New York. He is one of the world’s leading authorities on antimicrobial therapy and clinical infectious diseases. He has written/edited 1355 articles, 221 book chapters, and 36 books. He has received numerous teaching awards, including the Aesculapius Award for teaching excellence and the Spatz Award for clinical excellence. Dr. Cunha is a Master of the American College of Physicians, awarded for lifetime achievement as a Master Clinician and Master Teacher.
