1st Edition

Neurological Complications of Systemic Cancer and Antineoplastic Therapy

Edited By Herbert B. Newton, Mark G. Malkin Copyright 2010
    648 Pages 100 B/W Illustrations
    by CRC Press

    Neurological Complications of Systematic Cancer and Antineoplastic Therapy provides an in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses less common complications such as paraneoplastic disorders and neoplastic plexopathy.

    Highlights include:

    • The pathophysiology and molecular biology of cancer and the metastatic phenotype
    • Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses
    • Metabolic and nutritional disorders
    • CNS infections
    • Neurological complications of immunotherapy and bone marrow transplants

    Additional chapters review problems related to each specific tumor type, such as breast, lung, and colorectal, as well as gynecological cancer, genitourinary cancer, and malignant melanoma. The book also discusses neurological complications related to treatments such as radiation and chemotherapy.

    Bringing clinical trial knowledge from the bench to the bedside, this volume is an essential reference for the practicing oncologist and neurologist.

    Biology and pathophysiology of nervous system metastases

    Herbert B Newton and Mark G Malkin

    Intracranial metastases

    Herbert B Newton and Mark G Malkin

    Epidural metastasis and spinal cord compression

    Nader Pouratian, Mark E Shaffrey, and David Schiff

    Leptomeningeal metastasis

    Linda D Grossheim and Mark G Malkin

    Cranial nerve involvement by metastatic cancer

    Paul L Moots

    Cancer-related plexopathies

    Paul L Moots and Michael Edgeworth

    Cerebrovascular complications of malignancy

    Joseph Rudolph and Jeffrey M Katz

    Metabolic and nutritional nervous system dysfunction in cancer patients

    Herbert B Newton

    Central nervous system infections in cancer patients

    Amy A Pruitt

    Diagnosis and treatment of paraneoplastic neurological disorders

    Annick Desjardins

    Neurological complications of lung cancer

    Linda D Grossheim, Mark G Malkin, Suriya A Jayapalan, and John W Henson

    Neurological complications of breast cancer

    Neil E Anderson

    Neurological complications of malignant melanoma

    Maciej M Mrugala and John W Henson

    Neurological complications of leukemia and lymphoma

    Lynne P Taylor

    Neurological complications of head and neck cancer

    Marta Penas-Prado and Morris D Groves

    Neurological complications of gynecological cancers

    Susan C Pannullo, Eliana T Muskin, Robert D Zimmerman, and Jennifer A Moliterno

    Neurological complications of GI cancers

    Larry Junck and Mark M Zalupski

    Neurologic complications associated with genitourinary cancer

    Samer S Kasbari, Marc S Ernstoff, and Camilo E Fadul

    CNS complications of sarcoma

    Ed Olson and Jeffrey J Raizer

    Neurological complications of multiple myeloma

    Nina A Paleologos and Allison L Weathers

    Neurologic complications of cancer and its therapy during childhood

    Mark T Jennings

    Neurological complications of radiotherapy

    Jeremy Rudnick and Lauren E Abrey

    Neurological complications of chemotherapy

    April F Eichler and Patrick Y Wen

    Neurological complications of immunotherapy

    Florence Laigle-Donadey, Gentian Kaloshi, and Jean-Yves Delattre

    Neurological complications of steroids and of supportive care

    Willem-Johan van de Beek and Charles J Vecht

    Psychiatric aspects of care in the cancer patient

    William S Breitbart and Yesne Alici

    Chronic cancer pain syndromes and their treatment

    Nathan I Cherny

    Psychosocial issues

    Jane R Schubart, Elana Farace, and Robert Cavaliere

    Supportive care

    Herbert B Newton and Mark G Malkin

    Index

    Biography

    Herbert B. Newton, M.D., is Professor of Neurology, Co-Director, Dardinger Neuro-Oncology Center , Esther Dardinger Endowed Chair in Neuro-Oncology and Director in the Division of Neuro-Oncology at the Ohio State University Medical Center, Columbus, Ohio. Dr. Newton is also an Attending Physician in Neuro-Oncology at The Arthur G. James Cancer Hospital and Solove Research Institute and Staff Physician in the Section of Neurology at the Children's Hospital of Columbus. He is a diplomate of the American Board of Psychiatry and Neurology, a Fellow of the American Academy of Neurology and Royal Society of Medicine, and a member of numerous national and international societies.

    Mark G. Malkin M.D., is Chief of the Division of Neuro-oncology in the Department of Neurology, and Professor of Neurology and Neurosurgery at the Medical College of Wisconsin, Milwaukee, Wisconsin. Dr. Malkin is also on the active staff of Froedtert Memorial Lutheran Hospital, where he serves as Co-Chair of the Cancer Committee. He is a Fellow of both the Royal College of Physicians of Canada (Neurology) and the American Academy of Neurology. In 2005 he received the Excellence in Clinical Teaching Award from the Department of Neurology at the Medical College of Wisconsin.