2nd Edition

Percutaneous Penetration Enhancers

Edited By Eric Wane Smith, Howard Maibach Copyright 2006
    448 Pages 121 B/W Illustrations
    by CRC Press

    Thoroughly updated, this second edition is the most comprehensive reference on the methods available for the enhancement of percutaneous penetration. The book examines a broad scope of chemical enhancers and various physical methods of enhancement. The range of chemicals discussed is, arguably, unsurpassed anywhere in the literature. This edition contains comprehensive descriptions of the latest techniques and several chapters cover the modern analytical techniques adapted to assess and measure penetration enhancement. New to this volume are chapters addressing penetration retardation, important for substances such as sunscreen agents, for which skin penetration is not desirable.

    INTRODUCTION

    Penetration Enhancer Classification, B.W. Barry

    Structure–Activity Relationship of Chemical Penetration Enhancers, N. Kanikkannan, J.B. Ramapuram, and M. Singh

    Quantitative Structure–Enhancement Relationship and the Microenvironment of the Enhancer Site of Action, S.K. Li and W.I. Higuchi

    The Role of Prodrugs in Penetration Enhancement, K.B. Sloan and S.C. Wasdo

    VEHICLE EFFECTS IN PENETRATION ENHANCEMENT

    Penetration Enhancement by Skin Hydration, J. Zhang, C.H. Purdon, E.W. Smith, H.I. Maibach, and C. Surber

    Enhancement of Delivery with Transdermal Sprays, B.C. Finnin and J. Hadgraft

    Hydrogel Vehicles for Hydrophilic Compounds, T. Cerchiara and B. Luppi

    Enhanced Skin Permeation Using Ethosomes, E. Touitou and B. Godin

    Microemulsions in Topical Drug Delivery, S. Pappinen and A. Urtti

    Nanoparticles as Carriers for Enhanced Skin Penetration, S. Miyazaki

    Solid Lipid Nanoparticles for Topical Delivery, Z. Mei

    Fatty Alcohols and Fatty Acids, R.J. Babu, M. Singh, and N. Kanikkannan

    Essential Oils and Terpenes, R.A. Thakur, Y. Wang, and B.B. Michniak

    PHYSICAL METHODS OF PENETRATION ENHANCEMENT

    Iontophoresis: Clinical Applications and Future Challenges, N. Abla, A. Naik, R.H. Guy, and Y.N. Kalia

    Electroporation, B.M. Medi and J. Singh

    Micron, M.R. Prausnitz, J.A. Mikszta, and J. Raeder-Devens

    Vesicles under Voltage, M.C. Bonner and B.W. Barry

    ASSESSMENT OF PENETRATION ENHANCEMENT

    Mechanistic Studies of Permeation Enhancers, S.K. Li and W.I. Higuchi

    Penetration Enhancer Assessment by Corneoxenometry, C. Pie´rard-Franchimont, F. Henry, E. Uhoda, C. Flagothier, and G.E. Pie´rard

    Assessment of Vehicle Effects by Skin Stripping, C.H. Purdon, C. Pellanda, C. Surber, and E.W. Smith

    The Use of Skin Alternatives for Testing Percutaneous Penetration, C.S. Asbill, G.W. Bumgarner, and B.B. Michniak

    High Throughput Screening of Transdermal Penetration Enhancers: Opportunities, Methods, and Applications, A. Jain, P. Karande, and S. Mitragotri

    Confocal Laser Scanning Microscopy: An Excellent Tool for Tracking Compounds in the Skin, D.D. Verma and A. Fahr

    THE RETARDATION OF PERCUTANEOUS PENETRATION

    Fundamentals of Retarding Penetration, J. Hadgraft and B.C Finnin

    Retardation Strategies for Sunscreen Agents, C.H. Purdon, E.W. Smith, and C. Surber

    Military Perspectives in Chemical Penetration Retardation, E.H. Braue, Jr., B.F. Doxzon, H.L. Lumpkin, K.A. Hanssen, R.S. Stevenson, R.R. Deckert, and J.S. Graham

    COMMERCIAL APPLICATIONS OF PENETRATION ENHANCERS

    Preclinical and Clinical Development of a Penetration Enhancer SEPA 0009, T.C. K. Chan

    Index

    Biography

    Eric Wane Smith, Howard I. Maibach

    "Thoroughly updated, this second edition is the most complete reference on the methods available in the field. … This edition contains comprehensive descriptions of the latest techniques, and several chapters deal with the modern analytical techniques adapted to assess and measure penetration enhancement. … This volume elegantly sums up current research in the ever-broadening fields of topical penetration, enhancement and retardation. It establishes a broad framework for the topic and a foundation for continued research." —In Anticancer Research, Vol. 26, 2006

    "The book is an ideal and practical reference in Percutaneous Penetration Enhancers…designed for researchers, students, biomedical and pharmaceutical scientists." —International Journal of Biological Macromolecules, September 2006

    "Overall, I thought the book was a very well put together review of the field of percutaneous enhancers. It will be used by both experienced academics and young researchers to bring themselves quickly up to date in their areas of interest." —IFSCC  Magazine, Vol. 11, No. 1, 2008