1st Edition
Methods in Alcohol-Related Neuroscience Research
416 Pages
by
CRC Press
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Written by a panel of experts, Methods in Alcohol-Related Neuroscience Research not only provides information of a technical nature but also gives an overview of the many areas in investigating the effects of alcohol on the brain. It gives technical guidance for investigators doing research at the molecular, cellular, systems, and behavioral levels. These techniques include a wide variety of approaches, ranging from gene mapping and examination of molecular interactions of alcohol at the sub-cellular level to recording of neural activities in freely-behaving animals and imaging alcohol effects on the living human brain.
Quantitative Trait Locus Mapping in Mice. Knockout and Knockin Mice. Molecular Studies by Chimeragenesis and Mutagenesis. Combining Patch-Clamp Recording and Gene Profiling in Single Neurons. Quantitative Analysis of Neurotransmitter Receptor Expression with Antibody-Based Techniques. Artificial Bilayer Techniques in Ion Channel Study. Rapid Drug Superfusion and Kinetic Analysis. Electrophysiological Assessment of Synaptic Transmission in Brain Slices. Cognitive Correlates of Single Neuron Activity in Task-Performing Animals. Multichannel Neural Ensemble Recording during Alcohol Self-Administration. Combined Single-Neuron Recording and Microdialysis in the Brain of Freely-Behaving Animals. Quantitative Microdialysis for in vivo Studies of Pharmacodynamics. Structural MRI of the Human Brain. Biochemical, Functional and Microstructural MRI.
Biography
Yuan Liu, David M. Lovinger
