1st Edition

Interferon Therapy of Multiple Sclerosis

Edited By Anthony Reder Copyright 1997

    This reference presents cutting-edge basic and clinical research on all forms of interferon (IFN) involvement in the management of multiple sclerosis (MS)-detailing topics from IFN-receptor molecular interactions to synergy and interference with other agents such as cytotoxic drugs and chemotherapy. Features detailed research findings on IFN ß -1a (Avonex) and IFN -1b (Betaseron).

    The Molecular Biology of Interferon-ß from Receptor Binding to Transmembrane Signaling, Lawrence M. Pfeffer and Stefan N. Constantinescu
    The Molecular Biology of Type I Interferons (Interferon- /ß) (Gene Activation, Promoters, Proteins Induced), Thomas Decker
    Pharmacokinetics of Interferon-ß and the Biological Markers It Induces, Patricia L. Witt
    Interferons and the Central Nervous System Glia, Timothy Vartanian
    Effects of Interferon on the Central Nervous System, Nachum Dafny, Bertha Prieto-Gomez, and Cruz Reyes-Vazquez
    Neuropsychological Effects of Interferon Therapy, Neil H. Pliskin, Anthony T. Reder, and Diane S. Goldstein
    The Effects of Interferon-ß on Cytokines and Immune Responses, Peter Rieckmann
    The Pathogenetic Role of Interferon- in Multiple Sclerosis, Gianvito Martino and Luigi M. E. Grimaldi
    The Effects of Interferons and Other Cytokines on Experimental Autoimmune Encephalomyelitis, Hubertine Heremans and Alfons Billiau
    Effects of Oral Administration of Type I Interferons on Experimental Autoimmune Encephalomyelitis, Staley A. Brod
    Interferon- in the Treatment of Multiple Sclerosis, Lorne F. Kastrukoff and Joel J.-F. Oger
    Recombinant Interferon- in the Treatment of Multiple Sclerosis: Effects on Exacerbation Rate, Magnetic Resonance Imaging of Lesion Activity, and Cytokines, Luca Durelli
    Inteferon ß-1a Treatment of Multiple Sclerosis, Robert M. Herndon
    Inteferon ß-1b (Betaseron) Treatment of Multiple Sclerosis, Robert L. Knobler
    Effects of Inteferon ß-1b on Multiple Sclerosis Lesions Evaluated by Magnetic Resonance Imaging and Other Magnetic Resonance Techniques, Robert A. Koopmans, David K. B. Li, Guo Jun Zhao, Elana Brief, Alex MacKay, Irene Vavasour, Ken Whittall, and Donald W. Paty
    Adverse Effects of Interferons, Richard Cirelli, Kathleen B. Herne, Monica L. McCrary, and Stephen K. Tyring
    Interferon-t: A Potential Treatment for Inflammatory Central Nervous System Disease, Jeanne M. Soos, Joel Schiffenbauer, Howard M. Johnson, and Carol H. Pontzer
    Clinical Trials of Multiple Sclerosis, Jeremy C. Hobart and Alan J. Thompson
    The Incidence and Clinical Significance of Antibodies to Interferon-a, Kjell Öberg and Rachel M. McKenna
    Quantitation and Characterization of Multiple Sclerosis Patient Antibodies to Interferon-ß, Eirik Nestaas, James G. Files, Jeffrey W. Nelson, and Erno Pungor, Jr.

    Biography

    Anthony Reder

    "
    …an excellent reference for anyone interested in the basic mechanisms of action of the interferons and the clinical chapters provide a clear account of their role in the current management of patients with multiple sclerosis."-The Canadian Journal of Neurological Sciences, 1998