This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai
Series Introduction
Preface
Contributors
Part One
Fundamentals
Changing Needs in Drug Delivery in the Era of Peptide and Protein Drugs
Vincent H. L. Lee
Synthesis of Peptides and Proteins by Channnel and Biotechnological Means
Paul D. Gesellchen and Robert F. Santerre
Physical Biochemistry of Peptide Drugs: Structure, Properties, and Stabilities of Peptides Compared with Proteins
James Q. Oeswein and Steven J. Shire
Approaches to the Analysis of Peptides
Cynthia S. Randall, Thomas R. Malefyt, and Larry A. Sternson
Analysis of Protein Drugs
Rodney Pearlman and Tue H. Nguyen
Enzymatic Barriers to Peptide and Protein Drug Delivery
Vincent H. L. Lee, Robert D. Traver, and Mitchell E. Taub
Intestinal Epithelial and Vascular Endothelial Barriers to Peptide and Protein Delivery
Joffre Baker, Ismael J. Hidalgo, and Ronald T. Borchardt
Pharmacokinetics of Peptide and Protein Drugs
Udaya Bhaskar Kompella and Vincent H. L. Lee
Part Two
Routes of Delivery
Parental Delivery of Peptide and Protein Drugs
Partha S. Banerjee, Ehab A. Honsy, and Joseph R. Robinson
Buccal Routes of Peptide and Protein Drug Delivery
Hans P. Merkle, Reinhold Anders, Aloys Wermerskirchen, Susanne Raehs, and Gregor Wolany
Rectal Route of Peptide and Protein Drug Delivery
J. Howard Rytting
Nasal Route of Peptide and Protein Drug Delivery
Kenneth S. E. Su
Vaginal Route of Peptide and Protein Drug Delivery
Hiroaki Okada
Transdermal Route of Peptide and Protein Drug Delivery
Yie W. Chien
Oral Route of Peptide and Protein Drug Delivery
Vincent H. L. Lee, Satish Dodda-Kashi, George M. Grass, and Werner Rubas
Part Three
Pratical Considerations
Mucoadhesive Dosage Forms for Peptide and Protein Drug Delivery
Sau-Hung S. Leung, Tsuneji Nagai, and Yoshiharu Machida
Preformulation and Formulation Considerations of Peptide Drugs: Case History of and LHRH Analog
Shabbir T. Anik and David M. Johnson
Controlled Delivery Systems for Peptide
Lynda M. Sanders
Characterization of the Toxicity Profile of Peptide and Protein Therapeutics
B. J. Marafino, Jr., and J. R. Kopplin
Reduction of Imminogenicity and Extension of Circulating Half-Life of Peptides and Proteins
Frank F. Davis, Glen M. Kazo, Mary L. Nucci, and Abraham Abuchowski
Regulatory Prespective of Peptide and Protein Drug Development
John L. Gueriguian, Yuan-Yuan H. Chui, Alex Jordan, Carols A. Schaffernburg, and Solomen Sobel
Index
Biography
Vincent Lee
". . .extremely well written in terms of both clarity and organization of the material. . .. If you or your library does not already have a copy of this book, buy it immediately."
---Journal of Controlled Release
". . .provides exceptional detail."
---American Journal of Pharmaceutical Education
"An outstanding contribution to the field."
---Biomaterials
