1st Edition
Metal Ions in Biological Systems Volume 9: Amino Acids and Derivatives as Ambivalent Ligands
This book focuses on the connection between the chemistry of metal ions and their role for life, and covers complexes with a number of amino acids with chelatable side chain donor atoms. It discusses metal ion-protein interactions and the ligating ambivalency of nucleotides.
Preface to the Series
Preface to Volume 9
Contributors
Contents of other Volumes
Chapter 1
Complexes of a-Amino Acids with Chelatable Side Chain Donor Atoms
R. Bruce Martin
1. Scope
2. Stability Constant Comparisons
3. Asparagine and Glutamine
4. Serine and Threonine
5. Methionine and S-Methylcysteine
6. Cystine
7. a, w-Diaminocarboxylates
8. Histidine
9. Aromatic Side Chains
Abbreviations
Addendum
References
Chapter 2
Metal Comlexes of Aspartic Acid and Glutamic Acid
Christopher A. Evans, Roger Guevremont, and Dallas L. Rabenstein
1 Introduction
2 Acid-Base Chemistry
3 Comlexes with Main Group Metal Ions
4 Complexes with Transition Metals
5 Comlexes with Lanthanides and Actinides
Abbreviations and Defintions
References
Chapter 3
The Coordination Chemistry of L-Cysteine and D-Penicillamine
A. Gergely and I. Sovago
1. Introduction
2. Properties of Ligands
3. Complexes of Nontransition Elements
4. Complexes of the Transition Metals
5. Mixed Ligand Complexes
6. Conclusion
References
Chapter 4
Glutathinone and It’s Metal Complexes
Dallas L. Rabenstein, Roger Guevremont, and Christopher A. Evans
1 Introduction
2 Redox Chemistry of Glutathinone
3 Acid-Base Chemistry of Glutathinone
4 Coordination Chemistry of Reduced Glutathione
5. Coordination Chemistry of Oxidized Glutathinone
6. Summary
Abbreviations and Definitions
References
Chapter 5
Coordination Chemistry of L-Dopa and Related Ligands
A. Gergely and T. Kiss
1. Introduction
2. Chemical Characteristics of L-Dopa and Related Ligands
3. Metal Complexes of the Ligands
4. Implication of Metal Ions and Their Complexes in Biological Functions of Catecholamines
5. Conclusions
Abbreviations
References
Chapter 6
Stereoselectivity in the Metal Complexes of Amino Acids and Dipeptides
Leslie D. Pettit and Robert J. W. Hefford
1 Introduction
2 Amino Acid Complexes
3 Dipeptide Complexes
References
Chapter 7
Protonation and Complexation of Macromolecular Polypeptides: Corticortropin Fragments and Basic Trypsin Inhibitor (Kunitz Base)
Kalman Burger
1 Introduction
2 Protonation Equilibria
3 Complex Formation Equilibria
4 Conclusion
References
Author Index
Subject Index
Biography
Helmut Sigel
