1st Edition
Thermal Analysis of Pharmaceuticals
As a result of the Process Analytical Technologies (PAT) initiative launched by the U.S. Food and Drug Administration (FDA), analytical development is receiving more attention within the pharmaceutical industry. Illustrating the importance of analytical methodologies, Thermal Analysis of Pharmaceuticals presents reliable and versatile characterization tools for the successful development of pharmaceutical products. It draws attention to the most widely applicable methods and demonstrates how to interpret the associated data.
The book opens with the first three chapters devoted to differential scanning calorimetry (DSC), the most commonly used thermal method. These chapters cover the principles, optimal use, and pharmaceutical applications of the method. Subsequent chapters explore modulated temperature DSC, thermogravimetric analysis, thermal microscopy, microcalorimetry, high sensitivity DSC, dynamic mechanical analysis, and thermally stimulated current, all of which have attracted great interest within the pharmaceutical field. The chapters include theoretical background, measurement optimization, and pharmaceutical applications of each technique.
Exploring important techniques for characterizing the physical structure and properties of pharmaceutical materials, Thermal Analysis of Pharmaceuticals achieves an ideal balance in the depth, relevance, and accessibility of topics presented. The book provides an excellent overview of this key area in pharmaceutical development.
Biography
Duncan Q.M. Craig, Mike Reading
“… presents reliable and versatile characterization tools for the successful development of pharmaceutical products. It draws attention to the most widely applicable methods and demonstrates how to interpret the associated data. … achieves and ideal balance in the depth, relevance, and accessibility of topic presented. The book provides an excellent overview of this key area in pharmaceutical development.”
— In Anticancer Research, Vol. 27, No. 3B, May/June 2007"The editors did a really good job in creating a fine balance between topics of commonly used, well-established methods, and of techniques that are the focus of recent research efforts . . . Due to the high scientific value, timely industrial relevance, and didactic approach, this book is an invaluable information resource for readers both in academia and industry, be they beginners or experts. I warmly recommend this book to everybody involved in solid-state analysis of pharmaceuticals, because it is the must have that I have long been waiting for."
– Dr. Ádám Demeter, Gedeon Richter Plc, in ChemMedChem, 2008, No. 3
