1st Edition

Gene Therapy for Diseases of the Lung

Edited By Kenneth Brigham Copyright 1997

    This up-to-the-minute and comprehensive resource lucidly covers gene therapy for lung diseases from existing technologies delivering foreign DNA to the lungs via the airways or circulation to promising new approaches for the further development of safe and efficient gene delivery systems.

    Overview

    Human Gene Therapy: The Initial Concepts, W. French Anderson
    Discovering Genes That Cause Disease, Francis S. Collins

    Delivering Genes to Human Lungs

    Adenoviral Vectors for Gene Therapy of Inherited and Acquired Disorders of the Lung, David T. Curiel and Robert I. Garver, Jr.
    Adeno-Associated Virus-Based Delivery Systems, Pamela L. Zeitlin
    Cellular Responses to Adenovirus Entry, Susanna Chiocca and Matthew Cotton
    Catonic Lipid-Based Gene Delivery: An Update, Xiang Gao
    Liposome/Viral Hybrid Gene Delivery Systems, Arlene A. Stecenko

    Gene Therapy in the Lung: The Next Generation

    Manipulating the Intracellular Trafficking of Nucleic Acids, Kathleen E. B. Meyer, Lisa S. Uyechi, and Francis C. Szoka, Jr.
    Delivery of Genes Through the Lung Circulation, David M. Rodman and Elizabeth G. Nabel
    Targeting Gene Expression to the Lung, Jeffrey A. Whitsett and Stephan W. Glasser
    Strategies to Accomplish Targeted Gene Delivery Employing Tropism-Modified Adenoviral Vectors, Joanne T. Douglas and David T. Curiel

    Disease-Directed Gene Therapy

    Toward Correction of the Genetic Defect in Cystic Fibrosis, Larry G. Johnson and Richard C. Boucher
    Correction of the Genetic Defect in Alpha-1 Antitrypsin Deficiency by Somatic Gene Therapy, Randy C. Eisensmith and Savio L. C. Woo
    Gene Therapy for Chronic Inflammatory Diseases of the Lungs, Angelo E. Canonico
    Gene Therapy for Acute Diseases of the Lungs, Kenneth L. Brigham
    Gene Therapy for Lung Cancer, Choon-Taek Lee and David P. Carbone

    Epilogue

    The Regulatory Process and Gene Therapy, Suzanne Epstein
    Some Issues Affecting Progress Toward Human Gene Therapy and Potential Application to the Lung, Theodore Friedmann

    Biography

    Kenneth Brigham (Edited by)