1st Edition

Translational Research in Traumatic Brain Injury

Edited By Daniel Laskowitz, Gerald Grant Copyright 2015
    436 Pages 9 Color & 34 B/W Illustrations
    by CRC Press

    Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow.

    Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas:

    • Epidemiology
    • Pathophysiology
    • Diagnosis
    • Current treatment strategies and sequelae
    • Future therapies

    Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

    Epidemiology
    Peter Leo and Michael McCrea

    Sport-Related Traumatic Brain Injury

    Michael Clark and Kevin Guskiewicz

    Diffuse Axonal Injury

    Erik Su and Michael Bell

    Blood-Brain Barrier Pathophysiology following Traumatic Brain Injury

    Lulit Price, Christy Wilson, and Gerald Grant

    Cellular and Molecular Mechanisms of Secondary Neuronal Injury following Traumatic Brain Injury

    Kamesh Krishnamurthy and Daniel Laskowitz

    Neuroinflammation

    Finnian Hanrahan and Matthew Campbell

    Neurosteroids and Traumatic Brain Injury: Translating Biomarkers to Therapeutics; Overview and Pilot Investigations in Iraq and Afghanistan Era Veterans

    Christine E. Marx, Jennifer C. Naylor, Jason D. Kilts, Charlotte E. Dunn, Larry A. Tupler, Steven T. Szabo, Bruce P. Capehart, Rajendra A. Morey, Lawrence J. Shampine, and VA Mid-Atlantic MIRECC Workgroup

    Neuroplasticity after Traumatic Brain Injury

    YouRong Sophie Su, Annand Veeravagu, and Gerald Grant

    Genetic Influences in Traumatic Brain Injury

    Ellen R. Bennett, Karin Reuter-Rice, and Daniel T. Laskowitz

    Modeling Post-Traumatic Epilepsy for Therapy Development

    Giulia Curia, Clifford L. Eastman, John W. Miller, and Raimondo D’Ambrosio

    Translational Principles of Neuroprotective and Neurorestorative Therapy Testing in Animal Models of Traumatic Brain Injury

    Edward D. Hall

    Biomarkers of Traumatic Brain Injury and Their Relationship to Pathology

    Jin Zhang, Vikram Puvenna, and Damir Janigro

    Advanced Neuroimaging of Mild Traumatic Brain Injury

    Inga K. Koerte, Jakob Hufschmidt, Marc Muehlmann, Alexander P. Lin, and Martha E. Shenton

    Epilepsy after Traumatic Brain Injury

    Kan Ding, Puneet K. Gupta, and Ramon Diaz-Arrastia

    Intracranial Pressure Monitoring and Management

    Peter Le Roux

    Post-Traumatic Stress Disorder: Relationship to Traumatic Brain Injury and Approach to Treatment

    Jonathon R. Howlett and Murray B. Stein

    Traumatic Brain Injury and Potential for Neuromodulation

    Shivanand P. Lad

    Enhanced Functional Outcome from Traumatic Brain Injury with Brain-Machine Interface Neuromodulation: Neuroprosthetic Scaling in Relation to Injury Severity

    Dennis A. Turner

    Neurocognitive and Psychiatric Symptoms following Mild Traumatic Brain Injury

    Wesley R. Cole and Jason M. Bailie

    Biography

    Edited by

    Daniel Laskowitz, MD, MHS, professor of neurology, anesthesiology & neurobiology; and director, Neurovascular Laboratories, Duke University Medical Center, Durham, North Carolina, USA

    Gerald A. Grant, MD, FACS, division chief, Pediatric Neurosurgery; vice chair for pediatric neurosurgery and associate program director; and associate professor, Department of Neurosurgery; Stanford University/Lucile Packard Children's Hospital, California, USA