1st Edition

Male Infertility Diagnosis and Treatment

Edited By Sergio Oehninger, Thinus Kruger Copyright 2007
    496 Pages 100 B/W Illustrations
    by CRC Press

    Male factor infertility is a common problem in reproductive medicine and can have a significant effect of the outcome of IVF treatment. This comprehensive book covers the diagnosis and treatment of male factor infertility in depth. It opens with a section on the basic science underlying the production of male gametes. There is then a major section on diagnosis that will prove very useful to a wide range of andrologists, endocrinologists, and REIs faced with unpicking the problems facing infertile couples. The final section addresses management of the subfertile male, including endocrinologic, surgical, and ART interventions. The book is authored by a prestigious, international team of contributors.

    SECTION 1: BASIC CONCEPTS: SPERM PHYSIOLOGY AND PATHOLOGY





    1. Functional anatomy and molecular morphology of the spermatozoon



    2. Physiology and pathophysiology of sperm motility



    3. The pathophysiology and genetics of human male reproduction



    4. Contribution of the male gamete to fertilization and embryogenesis



    5. Genome architecture in human sperm cells: possible implications for male infertility and prediction of pregnancy outcome



    6. Sperm pathology: pathogenic mechanisms and fertility potential in assisted reproduction



    7. Testicular dysgenesis syndrome (TDS): biological and clinical significance





    SECTION 2: DIAGNOSIS OF MALE INFERTILITY





    8. Evaluation of the subfertile male



    9. The basic semen analysis



    10. Advances in automated sperm morphology evaluation



    11. Sperm morphology training and quality control programs are essential for clinically relevant results



    12. The role of the acrosome index in prediction of fertilization outcome



    13. Acrosome reaction: physiology and its value in clinical practice



    14. Sperm-zona pellucida binding assays



    15. Detection of DNA damage in sperm



    16. Chromosomal and genetic abnormalities in male fertility



    17. Reactive oxygen species and its impact on fertility



    18. How do we define male subfertility and what is the prevalence in the general population?



    19. DNA fragmentation and its influence on fertilization and pregnancy outcome



    20. The impact of the paternal factor on embryo quality and development: the embryologist’s point of view





    SECTION 3: THERAPEUTIC ALTERNATIVES FOR MALE INFERTILITY





    21. Clinical management of male infertility



    22. Urological interventions for the treatment of male infertility



    23. Medical treatment of male infertility



    24. Male tract infections: diagnosis and treatment



    25. Sperm-washing techniques for the HIV-infected male: rationale and experience



    26. Treatment of HIV discordant couples – the Italian experience



    27. Artificial insemination using homologous and donor semen



    28. Intracytoplasmic sperm injection: current status of the technique and outcome



    29. Sperm retrieval for intracytoplasmic sperm injection



    30. Hyaluronic acid binding by human sperm: andrology evaluation of male fertility and sperm selection for intracytoplasmic sperm injection



    31. In-vitro maturation of spermatozoa



    32. New developments in the evaluation and management of the infertile male



    Biography

    Professor Thinus F. Kruger MD FRCOG - Reproductive Biology Unit, Department of Obstetrics & Gynaecology, Tygerberg Hospital, Tygerberg, South Africa

    Professor Sergio Oehninger - Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, VA, USA