1st Edition
Percutaneous Mitral Leaflet Repair MitraClip Therapy for Mitral Regurgitation
Mitral regurgitation (MR) affects millions of patients worldwide. It is a progressive condition that can worsen when left untreated, possibly leading to compensatory remodeling of the left ventricle. This can result in reduced functional capacity, poor quality of life, repeat hospitalizations, and even death from heart failure. Open, arrested heart surgery has until now been the therapeutic treatment of choice. However, many high-risk patients cannot tolerate traditional heart surgery and continue to suffer from severe MR.
In Percutaneous Mitral Leaflet Repair: MitraClip Therapy for Mitral Regurgitation, international experts discuss the clinical application of percutaneous mitral valve therapies for this subsect of patients, focusing on the MitraClip device. These new therapeutic developments will form an essential component of the interventional cardiologists’ armamentarium in treating MR patients and will be of interest to every practicing cardiologist.
Key topics include:
- An overview of the anatomy and pathophysiology of the mitral valvular complex and MR
- EVEREST trial outcomes, and the development of percutaneous edge-to-edge repair
- Updates on the global experience with this new therapy
- Patient selection and the role of percutaneous therapies for high-risk patients
- Echocardiographic guidance, including practical tips for the use of transesophageal echocardiography during a procedure
- Step-by-step techniques, plus tips and tricks for getting the best results for your patients
- Special considerations for treating the returning MR repair patient
- Discussion of the European experience since CE approval
- Future directions in percutaneous mitral valve therapies
Foreword - Mehmet Oz
Foreword - Ferolyn T. Powell
Preface - Alfieri Ottavio
1. Anatomy of the Mitral Valvular Complex
Nicolas M. Van Mieghem, Jackie S. McGhie, Margot M. Bartelings
2. The Pathophysiology of Mitral Regurgitation
Blase A. Carabello
3. Genesis of the surgical edge-to-edge (E2E) repair
Ottavio Alfieri, Michele De Bonis MD
4. Outcomes from surgical edge-to-edge repair
Francesco Maisano
5. An overview of the literature on surgical mitral valve repair
Sophie Jones, Michael Argenziano, Allan Schwartz
6. Development of Percutaneous Edge-to-Edge Repair: The MitraClip Story
Frederick St Goar
7. MitraClip® System Design and History of Development
Troy Thornton, Liz McDermott,
8. EVEREST Trial Results
Alice Perlowski, Ted Feldman
9. Outcomes for Functional Mitral Regurgitation (FMR)
James B Hermiller
10. The role of percutaneous mitral repair for high risk patients
Patrick Whitlow
11. Echocardiographic Evaluation for Mitral Regurgitation Grading and Patient Selection
Ehrin J. Armstrong, Elyse Foster
12. Understanding the Limits of Patient Selection for Edge-to-Edge Repair
Jason Rogers, Ehrin J. Armstrong
13. The basic technique for the Evalve MitraClip procedure
Gretchen Gary, Ted Feldman
14. Procedural tips & tricks
Saibal Kar
15. Training and simulation
Scott Lim
16. Special techniques for FMR
Olaf Franzen
17. The European experience since CE approval
Corrado Tamborino, Gian Paolo Ussia, Valeria Cammalleri
18. An Interventionalist’s Approach to the Practical Use of TEE Guidance
Howard C. Herrmann
19. Echo guidance
Frank Silvestry
20. A Critical Appraisal of Edge-To-Edge Repair with the MitraClip
Peter C. Block
21. Technique for surgical removal of the MitraClip
Michael Argenziano, Lori Soni
22. Special considerations for MV repair after prior clip therapy
Subhasis Chatterjeea, David A. Heimansohnb, John C. Alexandera
23. Gross and histologic findings after MitraClip placement
Renu Vermani, Elena Ladich
24. Future directions in percutaneous mitral therapy
Ted Feldman, Fred St. Goar
Biography
Ted Feldman, MD, FESC FACC FSCAI is director, Cardiac Catheterization Laboratory at NorthShore University Health System and Evanston Hospital, IL, USA. He has been a contributor to the development of percutaneous valve therapies, beginning with balloon valvuloplasty in the 1980s, and now with new methods for catheter-based valve repair and replacement.
Frederick St Goar, MD, FACC is an interventional cardiologist with Advanced Cardiovascular Specialists and a director of the Fogarty Institute for Innovation at El Camino Hospital, Mt View, CA, USA. He was the physician founder of Evalve.
" … offers a unique, comprehensive overview of transcatheter edge-to-edge repair … ."
—Volkmar Falk, MD, in CardioPulse
