1st Edition

Deep Brain Stimulation and Epilepsy

By Hans O. Lüders Copyright 2003

    Deep brain stimulation has been used effectively for many years to treat patients suffering from Parkinson's disease. Now, neurologists and neurosurgeons are using electric pulse generators to block abnormal activity, i.e. epileptic fits. Promising research results indicate that electric pulses implanted deep in the brain can affect neurocircuitry and help stop oncoming seizures. Supplying a solid background on brain stimulation and its application to epilepsy, Deep Brain Stimulation and Epilepsy provides a historical overview, explores pathogenesis of brain stimulation, discusses animal experiments and human studies, and explores future prospects of brain stimulation for epileptic control. The editor and his team of contributors distill information drawn directly from the literature into one convenient resource.

    HISTORICAL OVERVIEW: BRAIN STIMULATION AND EPILEPSY
    Brain Stimulation and Epilepsy: Basic Overview and Novel Approaches, J. Lüders, I. Najm, and H.O. Lüders

    PATHOGENESIS OF BRAIN STIMULATION: ANIMAL STUDIES
    The Basal Ganglia: Overview, T. Subramanian
    The Subthalamic Nucleus: Anatomy and Neurophysiology, T. Wichmann
    Brain Stimulation and Epilepsy: Electrical Stimulus Characteristics, M.T. Rise
    Electrically Excitable Nerve-elements: Excitation Sites in Peripheral and Central Stimulation, W.M. Grill
    Control of Neuronal Activity by Electrical Fields: in vitro Models of Epilepsy, D.M. Durand and M. Bikson
    The Nigral Control of Epilepsy: Basal Ganglia Circuitry as a Substrate for Seizure Control, K. Gale
    High Frequency Direct Cortical Electrical Stimulation: An Animal Model of Induced Acute Focal Seizures, H. Shigeto, I. Najm, A. Boongird, D.R. Nair, C. Burrier, K.B. Baker, and H.O. Lüders

    PATHOGENESIS OF BRAIN STIMULATION: HUMAN STUDIES
    Cortico-cortical Evoked Potentials, R. Matsumoto, D.R. Nair, E. LaPresto, I. Najm, W. Bingaman, H. Shibasaki, and H.O. Lüders
    Repetitive Transcranial Magnetic Stimulation, G. Thut and A. Pascual-Leone
    High Frequency Subthalamic Nucleus Stimulation, E.B. Montgomery, J.R. Gale, and K.B. Baker
    Cortical Evoked Potentials from Deep Brain Stimulation, K.B. Baker and E.B. Montgomery, Jr.
    EEG Recording from the Subthalamic Nucleus in Patients with Epilepsy, D.S.Dinner, S. Neme, and H.O. Lüders
    EEG and the Anterior Thalamic Nucleus, B, Litt and S. Cranstoun

    EFFECT OF BRAIN STIMULATION ON EPILEPTIC SEIZURES: ANIMAL EXPERIMENTS
    Absence Seizures in the GAERS Model: Subthalamic Nucleus Stimulation, A.-L. Benabid, L. Vercueil, K. Bressand, M. Dematteis, A. Benazzouz, L. Minotti, and P. Kahane
    Focal Limbic Seizures Induced by Kainic Acid: Effects of Bilateral Subthalamic Nucleus Stimulation, A. Pan, A. Boongird, T. Kunieda, I. Najm, and H.O. Lüders
    Focal Stimulation versus Deep Brain Stimulation, T. Tanaka, K. Hashizume, A. Matsuo, T. Urino, H. Tsuda, K. Kato, A. Hodozuka, and H. Nakai
    The Anterior Thalamus and the Pentylenetrazol (PTZ) Model, M.A. Mirski, D.L. Sherman, and W.C. Ziai

    EFFECT OF BRAIN STIMULATION ON EPILEPTIC SEIZURES: HUMAN STUDIES
    Vagal Nerve Stimulation: Surgical Techniques, W.E. Bingaman
    Vagal Nerve Stimulation: Effects on Seizures, D. Labar
    Therapeutic Prospects and Safety of Transcranial Magnetic Stimulation in Epilepsy, F. Tergau and B. Steinhoff
    Direct Cortical Electrical Stimulation in the Treatment of Epilepsy, D.R. Nair, R. Matsumoto, H.O. Lüders, R. Burgess, and W. Bingaman
    Electical Neuromodulation of the Epileptic Focus in Caes of Temporal Lobe Seizures, F. Velasco, A.L. Velasco, M. Velasco, L. Rocha, and D. Menes
    Anterior Thalamic Nucleus Stimulation: Surgical Procedure, G. Baluch
    Anterior Thalamic Nucleus Stimulation: Issues in Study Design, R.S. Fisher
    Surgical Procedure for Subthalamic Nucleus Stimulation, J.M. Rosenow, A. Boongrid, N.M. Boulis, A. Rezai
    Subthalamic Nucleus and Substantia Nigra Pars Reticulata Stimulation: The Grenoble Experience, A.-L. Benabid, A. Koudsie, S. Chabardes, L. Vercueil, A. Benazzouz, L. Minotti, J.-F. Le Bas, P. Kahane, A. de Saint Martin, and E. Hirsch
    Subthalamic Nucleus Stimulation in Patients with Intractable Epilepsy: The Cleveland Experience, S. Neme, E.B. Montgomery, Jr., A. Rezai, K. Wilson, and H.O. Lüders

    BRIAN STIMULATION: FUTURE PROSPECTS
    The Future of Brain Stimulation for Seizure Control, W. Heetderks

    Biography

    Hans O. Luders (Author)

    'This is the definitive account of the state of play of deep brain stimulation in epilepsy. It is a scholarly work, and covers the entire body of knowledge in this area, both in terms of animal and human studies. It is likely to be the definitive text in this specialised area.' - Highly Commended, Neurology Category, 2004 BMA Medical Book Competition

    'This is a welcome addition for anyone interested in electrophysiology, epilepsy, and the therapeutic effects of electrical impulses.' - British Journal of Neurosurgery, Volume 102, June 2005