1st Edition

Micro Reaction Technology in Organic Synthesis

By Charlotte Wiles, Paul Watts Copyright 2011
    454 Pages 327 B/W Illustrations
    by CRC Press

    466 Pages 327 B/W Illustrations
    by CRC Press

    While continuous processes have found widespread application within chemical production, members of the research and development communities have historically favored the centuries old technique of iterative batch reactions. With the exception of combinatorial and microwave chemistry, little had been done to change the way that synthetic chemists conduct their research. However, today’s synthetic chemist is under increasing pressure to discover and deliver compounds quickly, with an eye on devising scalable synthetic methodologies.





    An up-to-date account of recent developments in continuous flow organic synthesis, Micro Reaction Technology in Organic Synthesis is a useful resource for those both new to, and actively researching within, the field of micro reaction technology.









    • Written by chemists for chemists, key synthetic information takes precedence over technological details


    • Highlights the advantages and disadvantages of the technology, giving the reader an idea of where future research needs to be targeted


    • Presents a comprehensive collection of synthetic reactions that have been investigated over the past decade, therefore is a one-stop resource to the reactions and techniques that have been investigated so far






    With an ever increasing number of commercial flow reaction platforms available, this book highlights the current state of the technology with the vision that more synthetic chemists will embark upon flow chemistry programs of research, facilitating the identification of novel synthetic methodologies the potential to be scaled directly to production.

    Introduction to Micro Reaction Technology
    What is Micro Reaction Technology?
    Fabrication/Construction of Micro Reactors
    Manipulation of Reactants and Products within Flow Reactors
    Advantages of Micro Reaction Technology
    Disadvantages of Micro Reactors
    Process Intensification
    In Situ Reaction Monitoring
    Commercial Availability of Continuous Flow
    Outlook
    References

    Micro Reactions Employing a Gaseous Component

    Gas-Phase Micro Reactions
    Gas–Liquid-Phase Micro Reactions
    Gas–Liquid–Solid Micro Reactions
    References

    Liquid-Phase Micro Reactions

    Nucleophilic Substitution
    Electrophilic Substitution
    Nucleophilic Addition
    Elimination Reactions
    Oxidations
    Reductions
    Metal-Catalyzed Cross-Coupling Reactions
    Rearrangements
    Multistep/Multicomponent Liquid-Phase Reactions
    Summary
    References

    Multi-Phase Micro Reactions

    Nucleophilic Substitution
    Electrophilic Substitution
    Nucleophilic Addition
    Elimination Reactions
    Oxidation Reactions
    Metal-Catalyzed Cross-Coupling Reactions
    Rearrangements
    Enantioselective Reactions
    Multistep/Multicomponent Reactions
    Summary
    References

    Electrochemical and Photochemical Applications of Micro Reaction Technology
    Electrochemical Synthesis under Continuous Flow
    Photochemical Synthesis under Continuous Flow
    Multiphase Photochemical Reactions
    References

    The Use of Microfluidic Devices for the Preparation and Manipulation of Droplets and Inorganic/Organic Particles
    Droplet Formation using Continuous Flow Methodology
    Preparation of Inorganic Nanoparticles under Continuous Processing Conditions
    Formation of Organic Particles within Continuous Flow Devices
    The Use of Micro Reactors for the Postsynthetic Manipulation of Organic Compounds
    Mixed Particle Formation
    Summary
    References

    Industrial Interest in Micro Reaction Technology

    MRT in Production Environments
    Synthesis of Fine Chemicals Using Micro Reactors
    Synthesis of Pharmaceuticals and Natural Products using Continuous Flow Methodology
    Synthesis of Small Doses of Radiopharmaceuticals
    Summary
    References

    Microscale Continuous Separations and Purifications

    Introduction
    Liquid–Liquid Extractions
    Gas–Liquid Separation
    Solvent Exchange and Solvent Removal
    The Use of Scavenger Resins for Product Purification under Flow
    Continuous Flow Resolutions
    Product Isolation
    Summary
    References

    Biography

    Charlotte Wiles, Paul Watts

    "Although there have been several books devoted to Micro Reaction Technology over the past decade, there has not been a volume focussed on the needs of the organic chemist. This excellent new book fulfils that gap."
    —Trevor Laird, in Organic Process Research, March 2011

    "In contrast to some of the other books available on this subject, this is clearly a book written by chemists for chemists. In a relatively short and easy-to-follow introductory chapter, the fundamentals of micro reaction technology, including fabrication of devices, pumping and mixing issues, and advantages/disadvantages, are explained with the synthetic chemist in mind. In each of tile sub chapters, the reader is pointed toward appropriate key references, review articles, or other books that provide further details on the subject."
    American Chemical Society, 2011