2nd Edition

Bioactive Natural Products Detection, Isolation, and Structural Determination, Second Edition

Edited By Steven M. Colegate, Russell J. Molyneux Copyright 2008
    620 Pages 314 B/W Illustrations
    by CRC Press

    Following the successful format of the original, this new edition presents applications of the most recent techniques for the detection, isolation, and structural determination of bioactive natural products. It features new case studies and illustrations that demonstrate applications of techniques covered in the book. Complementing as much as replacing the first edition, most of the contributors are new. The text includes updates on chemical extraction, and NMR-based structure determination, and new contributions on liquid chromatography linked with mass and NMR spectroscopy, dereplication approaches, assessment of source material for natural products and novel bioassay development.

    Introduction and Overview
    Detection and Isolation of Bioactive Natural Products
    Nuclear Magnetic Resonance Spectroscopy: Strategies for Structure Determination
    Quantitative NMR of Bioactive Natural Products
    Development and Application of LC-NMR Techniques to the Identification of Bioactive Natural Products
    Determination of the Absolute Configuration of Bioactive Natural Products using Exciton Chirality Circular Dichroism
    Separation of Enantiomeric Mixtures of Alkaloids and their Biological Evaluation
    UV Dereplication of Natural Products Extracts
    Liquid Chromatography-Mass Spectrometry in Natural Product Research
    Application of High-Speed Counter-Current Chromatography to the Isolation of Bioactive Natural Products
    Biosensing Approach in Natural Products Research
    Anticancer Drug Discovery and Development from Natural Products
    Sourcing Natural Products from Endophytic Microbes
    Isolation of Bioactive Natural Products from Myxobacteria
    Naturally-occurring Glycosidase Inhibitors
    Bioassay-Directed Isolation and Identification of Anti-aflatoxigenic
    Constituents of Walnuts
    Bioactive Peptides in Hen Eggs
    Biological Fingerprinting Analysis: Strategy for Screening of Bioactive Compounds in Traditional Chinese Medicines
    Antimalarial Compounds from Traditionally-used Medicinal Plants
    Germination Stimulant in Smoke:  Isolation and Identification
    Plant-associated Toxins: Bioactivity-guided Isolation, Elisa and LCMS Detection

    Biography

    Steven M. Colegate, Russell J. Molyneux

    "Overall, Bioactive Natural Products, 2nd edition is a book that can be read from cover to cover for both benefit and pleasure. Thus. I highly recommend this book for active natural products scientists, not only for its quality and timeliness but also for its projection of the multidisciplinary nature of natural products research."
    --Ehab A. Abourashed, Chicago State University

    "Overall, Bioactive Natural Products, 2nd edition is a book that can be read from cover to cover for both benefit and pleasure. Thus. I highly recommend this book for active natural products scientists, not only for its quality and timeliness but also for its projection of the multidisciplinary nature of natural products research. "
    --Ehab A. Abourashed, Chicago State University

    "This is a hefty book; not that this is a criticism. With 605 pages of relatively small print the volume contains a wealth of information...Photographs, chemical structures, schemes, flow diagrams, graphs, chromatographic spectra, formulae both mathematical and chemical, and compendial tables add to this epic work...it is certainly worthy of a place on the bookshelf, if not open (health and safety issues here?) on the laboratory bench."
    --Steve Mitchell, Faculty of Medicine, Imperial College London

    "As evidenced by their publishing histories, these new contributors were chosen because of their familiarity with their topics and their personal research in the areas addressed. … should in the library of every department that is involved in natural product research. Everyone who has the first edition will value this second edition equally, if not more so, as its complementary extension."
    – Robert J. Krueger, Department of Pharmaceutical Sciences, Ferris State University, Michigan in Journal of Medicinal Chemistry, Vol. 51, No. 12, 2008

    "The editors did a fine job of organizing the chapters into a cohesive book . . . The main strength of the book is the combination of real-world examples. This enables natural products chemists to apply their principles outlined in the book to their own specific application . . . would be an invaluable resource for those researchers involved with natural product chemistry, and it would also be very useful for those analytical chemists involved in the characterization of botanicals."
    – Mark C. Roman, President, Tampa Bay Analytical Research, Inc., in HerbalGram, Nov 2008- Jan 2009, No. 80