Pharmaceutical Science

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Handbook of Statistics in Clinical Oncology, Third Edition

John Crowley, Antje Hoering
September 12, 2017

Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been...

Dermatokinetics of Therapeutic Agents

S. Narasimha Murthy
September 12, 2017

Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of...

Embedding New Technologies into Society: A Regulatory, Ethical and Societal Perspective

Diana M. Bowman, Elen Stokes, Arie Rip
September 11, 2017

The embedding of any new technologies in society is challenging. The evolving state of the scientific art, often-unquantifiable risks and ill-defined developmental trajectories have the potential to hinder innovation and/or the commercial success of a technology. The are, however, a number of tools...

Cancer Vaccines: From Research to Clinical Practice

Adrian Bot, Mihail Obrocea, Francesco M. Marincola
September 11, 2017

Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: From Research to Clinical Practice is the first...

Biomedical Application of Nanoparticles

Bertrand Henri Rihn
September 07, 2017

Biomedical Application of Nanoparticles explores nanoparticles, their chemical and physicals properties, and how they interact in biological systems with proteins, immune system and targeted cells. Risk assessment of nanoparticles for human is described, including: cellular paradigms,...

Sample Size Calculations in Clinical Research, Third Edition

Shein-Chung Chow, Jun Shao, Hansheng Wang, Yuliya Lokhnygina
August 30, 2017

Praise for the Second Edition: "… this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics "This impressive book contains formulae for computing sample size...

Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders

Andreia Ascenso, Helena Ribeiro, Sandra Simões
August 18, 2017

This book presents new approaches for skin aging and photocarcinogenesis and topical formulations based on nanocarrier systems for skin disorders. It discusses cosmeceuticals, laser, photodynamic therapy, and melatonin-based treatments as important strategies for photoaging management. Photodynamic...

Multicomponent Reactions: Synthesis of Bioactive Heterocycles

K.L. Ameta, Ph.D., Anshu Dandia
August 16, 2017

This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach. The majority of pharmaceuticals and biologically active agrochemicals are heterocycles while countless additives and modifiers used in industrial...

Functional Hydrogels in Drug Delivery: Key Features and Future Perspectives

Umile Gianfranco Spizzirri, Giuseppe Cirillo
August 16, 2017

The book deals with the synthesis and characterization of hydrogels specifically used as drug delivery systems. Each chapter includes the most recent updates about the different starting materials employed and the improvement of their physicochemical and biological properties to synthetize high...

Nonclinical Drug Administration: Formulations, Routes and Regimens for Solving Drug Delivery Problems in Animal Model Systems

Shayne C. Gad, Charles B. Spainhour
August 15, 2017

If we will ever achieve Paul Ehrlich’s "magic bullet," that is, a molecule which goes with high selectivity to the therapeutic target site, does what it needs to do, and is subsequently cleared from the body, the practice of safety assessment will have to change. Nonclinical Drug Administration:...

Capillary Electrophoresis: Trends and Developments in Pharmaceutical Research

Suvardhan Kanchi, Salvador Sagrado, Myalo I. Sabela, Krishna Bisetty
August 10, 2017

Capillary electrophoresis (CE) has become an established method with widespread recognition as an analytical technique of choice in numerous analytical laboratories, including industrial and academic sectors. Pharmaceutical and biochemical research and quality control are the most important CE...

Advances in Chromatography: Volume 54

Nelu Grinberg, Eli Grushka
August 10, 2017

For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 54, the series editors have invited established, well-known...