Pharmaceutical Science

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The Inhibitor Index: A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads

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Daniel Purich
June 12, 2017

Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a proce...

Pharmaceutical Dosage Forms: Capsules

Larry L. Augsburger, Stephen W. Hoag
November 09, 2017

Pharmaceutical Dosage Forms: Capsules covers the development, composition, and manufacture of capsules. Despite the important role that capsules play in drug delivery and product development, few comprehensive texts on the science and technology of capsules have been available for the research and...

Tuning Innovation with Biotechnology

Dong Hwa Kim
November 07, 2017

This book deals with evolving intelligence systems and their use in immune algorithm (IM), particle swarm optimization (PSO), bacterial foraging (BF), and hybrid intelligent system to improve plants, robots, etc. It discusses the motivation behind research on and background of evolving intelligence...

Biomotors: Linear, Rotation, and Revolution Motion Mechanisms

Peixuan Guo, Zhengyi Zhao
November 01, 2017

This book provides a comprehensive overview of biomotors (molecular motors) within the body with a specific concentration on revolving molecular motors. The bioengineering of these new revolving molecular motors will go a long way in creating machines that will be able to carry RNA and DNA drugs...

Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery

Graca Soveral, Soren Nielsen, Angela Casini
November 01, 2017

Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology. The studies have also shown aquaporins as potential drug targets and targets for improving crop...

Neurobiology of Huntington’s Disease: Applications to Drug Discovery

Donald C. Lo, Robert E. Hughes
October 31, 2017

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse...

Noninvasive Molecular Markers in Gynecologic Cancers

Debmalya Barh, Mehmet Gunduz
October 31, 2017

Early detection is critical for any given cancer. With the advent of the latest omics technologies, molecular markers in combination with conventional diagnostic and screening methods are emerging as next-generation early diagnostic and prognostic strategies that can allow early-stage diagnosis,...

Handbook of Pharmaceutical Manufacturing Formulations: Volume Three, Liquid Products

Sarfaraz K. Niazi
October 31, 2017

While liquid drugs do not share the compression problems of solid dosage forms, the filling problems of powder dosage forms, or the consistency problems of semisolid dosage forms, they do have their own set of considerations in the formulation and manufacturing stages. Highlights from Liquid...

Toxicologic Pathology: Nonclinical Safety Assessment

Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, Chirukandath Gopinath
October 23, 2017

As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical...

RNA Nanotechnology and Therapeutics

Peixuan Guo, Farzin Haque
October 23, 2017

Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in...

Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders

Andreia Ascenso, Helena Ribeiro, Sandra Simões
October 18, 2017

This book presents new approaches for skin aging and photocarcinogenesis and topical formulations based on nanocarrier systems for skin disorders. It discusses cosmeceuticals, laser, photodynamic therapy, and melatonin-based treatments as important strategies for photoaging management. Photodynamic...

Sedimentation Velocity Analytical Ultracentrifugation: Interacting Systems

Peter Schuck, Huaying Zhao
October 04, 2017

Analytical ultracentrifugation is one of the most powerful solution techniques for the study of macromolecular interactions, to define the number and stoichiometry of complexes formed, and to measure affinities ranging from very strong to very weak and repulsive. Building on the data analysis...

Biosimilars and Interchangeable Biologics: Strategic Elements

Sarfaraz K. Niazi
September 30, 2017

What’s the Deal with Biosimilars? Biosimilars are gaining momentum as new protein therapeutic candidates that can help fill a vital need in the healthcare industry. The biological drugs are produced by recombinant DNA technology that allows for large-scale production and an overall reduction time...

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