The concept of photoacoustic tomography (PAT) emerged in the mid-1990s, and the field of PAT is now rapidly moving forward. Presenting the research of a well-respected pioneer and leading expert, Photoacoustic Tomography is a first-of-its-kind book covering the underlying principles and practical applications of PAT in a systematic manner. Written in a tutorial format, the text:
- Addresses the fundamentals of PAT, the theory on photoacoustic effect, image reconstruction methods, and instrumentation
- Details advanced methods for quantitative PAT, which allow the recovery of tissue optical absorption coefficient and/or acoustic properties
- Explores the development of several image-enhancing schemes, including both software and hardware approaches
- Examines array-based PAT systems that are the foundation for the realization of 2-D, 3-D, and 4-D PAT
- Discusses photoacoustic microscopy (PAM) and combinations of PAT/PAM with other imaging methods
- Considers contrast-agents-based molecular PAT, with both nontargeted and cell receptor–targeted methods
- Describes clinical applications and animal studies in breast cancer detection, osteoarthritis diagnosis, seizure localization, intravascular imaging, and image-guided cancer therapy
Photoacoustic Tomography is an essential reference for graduate students, researchers, industry professionals, and those who wish to enter this exciting field.
Preface
About the Author
Fundamentals of Photoacoustic Tomography
Photoacoustic Effect
Empirical Description
Rigorous Theory
Image Reconstruction Methods
Delay-and-Sum Beam Forming Algorithm
Iterative Nonlinear Algorithm
A-Line/B-Mode Image Formation Method
Instrumentation
Quantitative Photoacoustic Tomography
Recovery of Optical Absorption Coefficient: Method 1
Recovery of Optical Absorption Coefficient: Method 2
Recovery of Optical Absorption Coefficient: Method 3
Recovery of Optical Absorption Coefficient: Method 4
Simultaneous Recovery of Optical Absorption Coefficient and Acoustic Velocity
Multispectral PAT
Image Enhancement Software and Hardware Approaches
Dual Mesh Scheme
Adjoint Sensitivity Method
Total-Variation-Minimization Scheme
Mathematical Derivations
Examples: Reduction of Noise Effect
Examples: Image Reconstruction from Few-Detector and Limited-Angle Data
Radiative Transfer Equation
The RTE and Its Finite Element Discretization
The RTE-Based Quantitative PAT
Results and Discussion
Parallel Computation
Variable-Thickness Multilayered Polyvinylidene Fluoride Transducer
AlN-Based Piezoelectric Micromachined Ultrasonic Transducer
Liquid Acoustic Lens
Microelectromechanical Systems Scanning Mirror
Photoacoustic Imaging System
Results and Discussion
Transducer Array-Based Photoacoustic Tomography: 2-D, 3-D, and 4-D Photoacoustic Imaging
Array-Based PAT System and 2-D Imaging
Laser Source
Full-Ring Ultrasound Transducer Array
Control Electronics and Data Acquisition
System Evaluation and Experimental Studies
3-D Imaging
System Description
Phantom Experiments
In Vivo Experiments
4-D Imaging
Drug Delivery Monitoring
Tumor Therapy Monitoring
Photoacoustic Microscopy and Photoacoustic Computed Microscopy
Optical-Resolution Photoacoustic Microscopy
Acoustic-Resolution Photoacoustic Microscopy
C-Scan Photoacoustic Microscopy
Materials and Methods
Results and Discussion
Photoacoustic Computed Microscopy
Methods
Results
Discussion
Photoacoustic Microscopy Based on Acoustic Lens with Variable Focal Length
Confocal Photoacoustic Microscopy Using a Single Multifunctional Lens
Multimodal Approaches
PAT/DOT
Material and Methods
Results and Discussion
PAT/FMT
Methods
Results and Discussion
PAT/Ultrasound
Optical-Resolution PAM/OCT
Materials and Methods
Results and Discussion
Contrast-Agents-Based Molecular Photoacoustic Tomography
Gold Nanoparticles
Graphene Nanosheets
Urokinase Plasminogen Activator Receptor (uPAR)–Targeted Magnetic Iron Oxide Nanoparticles (NIR830-ATF-IONP)
Material and Methods
Results
Discussion
HER-2/neu Targeted Magnetic Iron Oxide Nanoparticles for Dual-Modal Photoacoustic and Fluorescence Molecular Tomography (PAT/FMT) of Ovarian Cancer
Methods
Results
Discussion
Clinical Applications and Animal Studies
Joint Imaging
2-D Single-Spectral Quantitative PAT
2-D Multispectral Quantitative PAT
3-D Single-Spectral Quantitative PAT
3-D Multispectral Quantitative PAT
Intraoperative Imaging
Intraoperative Photoacoustic Tomography (iPAT) System
Results and Discussion
Brain Imaging
Methods
Results and Discussion
Imaging of Tumor Vasculature Development
Methods
Results and Discussion
Intravascular Imaging
Breast Imaging
Photoacoustic Tomography System
Clinical Experiments
Bibliography
Biography
Huabei Jiang, Ph.D, is J. Crayton Pruitt family professor in the Department of Biomedical Engineering at the University of Florida, Gainesville, USA. He has published more than 300 peer-reviewed scientific articles and patents. Dr. Jiang is a fellow of the Optical Society of America (OSA), a fellow of the International Society of Optical Engineering (SPIE), and a fellow of the American Institute of Medical and Biological Engineering (AIMBE).
"... a comprehensive accounting of photoacoustic imaging (PAI) methods and related technologies with emphasis on the author's own works. ... [a] timely addition to attract readers to this fascinating and relatively new area of research. The book uniquely covers the fundamentals of photoacoustic imaging with descriptions of basic physics, image reconstruction, software development, and implementation. The readers are also exposed to a short account of exogenous probes for PAI application and a few examples of PAI in clinical studies. The book provides a list of relevant references and further reading materials at the end of each chapter. The format of writing is tutorial and therefore I envision it as a reference text for graduate students, biomedical researchers, and engineers who want to embark into this exciting new imaging area."
—Dipanjan Pan, from IEEE Transactions on Medical Imaging, Vol. 34, No. 12, December 2015"… a very comprehensive collection of photoacoustic imaging methods, covering everything from the basics of photoacoustic generation and image reconstruction methods to the various implementations, including numerous applications. This is the first time the topic of photoacoustic imaging has been covered in this detail by a single author."
—Günther Paltauf, Karl-Franzens-Universität Graz, Austria
