1st Edition

Glutamine Biochemistry, Physiology, and Clinical Applications

Edited By Dominique Meynial-Denis Copyright 2017
    410 Pages 8 Color & 66 B/W Illustrations
    by CRC Press

    412 Pages 8 Color & 66 B/W Illustrations
    by CRC Press

    410 Pages 8 Color & 66 B/W Illustrations
    by CRC Press

    Glutamine: Biochemistry, Physiology, and Clinical Applications describes the different functions of glutamine (Gln) in animals and humans. Gln is both a nutrient and a signaling molecule, and its functions go beyond those of a simple metabolic fuel or protein precursor. This book has gathered together, in an unbiased and critical manner, all the available evidence and research on Gln including pathology (neurological diseases, intestinal diseases, critical illness, and cancer), physiology (successful aging), catabolic states, immunity, and exercise. Special attention is given to the potential benefit of Gln in states of insulin resistance and the role of Gln as a "conditionally essential" amino acid.



    The contributors are either pioneers or experts in the area of Gln from all around the globe, including Australia, Brazil, Canada, Europe, China, and the United States. This book is a valuable source of information for nutrition scientists, medical doctors, sports scientists, food scientists, dietitians, and anyone interested in nutrition. It is also a valuable resource for students in these fields and will be an important addition to university libraries.

    INTRODUCTION
    Morey W. Haymond

    BASICS OF GLUTAMINE METABOLISM

    An introduction to glutamine metabolism
    Vinicius Cruzat and Philip Newsholme

    NEW DATA ON THE BIOCHEMISTRY OF GLUTAMINE

    Intestinal glutamine synthetase co-localizes with goblet cells and decreases enterocyte proliferation
    Youji He, Theodorus BM Hakvoort, Jacqueline LM Vermeulen and Wouter H. Lamers

    Glutaminase isoforms and glutamine metabolism
    Curthoys et al.

    MOLECULAR AND CELLULAR ASPECTS OF GLUTAMINE METABOLISM

    The importance of glutamine to insulin secretion, insulin action and glycaemic control
    Vinicius Cruzat, Gaewyn Ellison, Cyril Mamotte and Philip Newsholme

    Glutamine and autophagy
    Rolf Gebhardt

    Novel aspects on the regulation of glutamine and ammonia metabolism by morphogens
    Rolf Gebhardt, Jan Böttger, Eugenia Marbach, Madlen Matz-Soja

    GLUTAMINE, THE BRAIN AND NEUROLOGICAL DISEASES

    The role of glutamine in brain pathology
    Albrecht et al.

    Brain glutamine and hepatic encephalopathy
    Roger F. Butterworth and Chantal Bemeur

    Change of glutamate/glutamine amounts in the striatum in a murin model of Parkinson's disease
    Carine Chassain1, Guy Bielicki2, Jean-Pierre Renou3, Franck Durif1,4

    GLUTAMINE AND THE INTESTINAL TRACT

    Glutamine and intestinal physiology and physiopathology
    François Blachier1, Xiangfeng Kong2, Guoyao Wu3, Daniel Tomé1, Antonio Lancha Jr4, Mireille Andriamihaja1, Yulong Yin2

    Glutamine: General Facilitator of Gut Absorption and Repair
    Rhoads et al.

    Therapeutic role of glutamine in inflammatory bowel disease
    Hongyu Xue and Paul Wischmeyer

    GLUTAMINE AND THE CATABOLIC STATE

    PART I: ROLE OF GLUTAMINE IN CRITICAL ILLNESS

    SECTION A: DURING CHILDHOOD

    Glutamine in the Critically Ill Neonate
    Neu et al

    SECTION B: FROM ADULTHOOD

    Rationale for and efficacy of glutamine supplementation in critical illness
    Farook Jahoor, Christina Kao

    The Role of Glutamine and Oxidative Injury Pathways in Critically Ill Patients
    Naji Abumrad, Kaushik Mukherjee and Addison May

    Glutamine supplementation in critical illness: clinical endpoints
    Marie Smedberg and Jan Wernerman

    Glutamine supplementation in critical illness: action mechanisms
    Moïse Coëffier and Pierre Déchelotte

    The clinical role of glutamine supplementation in disease
    Giacomo Garibotto, Alice Bonanni, Giacomo Deferrari, Daniela Verzola

    PART II: ROLE OF GLUTAMINE IN CANCER

    Glutamine transport and metabolism in cancer
    Paige J. Bothwell, Clare C. Kron and Barrie P. Bode

    Glutamine as a new therapeutic target in cancer: use of hyperpolarized magnetic resonance spectroscopy
    Dominique Meynial-Denis1 and Jean-Pierre Renou2

    GLUTAMINE, IMMUNITY AND EXERCISE

    Glutamine and the immune system: an overview
    Philip Calder

    Glutamine and exercise and immune system
    Marcelo Macedo Rogero

    The Role of Glutamine in Exercise-induced Immunodepression in Humans
    Lindy Castell and Natalie Redgrave

    GLUTAMINE AND AGING

    Glutamine metabolism in old age
    Dominique Meynial-Denis

    Biography

    Dominique Meynial-Denis, Ph.D., is a Researcher at Laboratoire d'Etude de Metabolisme Azote INRA, Centre de Recherches de Clermont-Ferrand-Theix, Lyon, France.