1st Edition

Computational Methods for Reproductive and Developmental Toxicology

Edited By Donald R. Mattison Copyright 2016
    344 Pages 52 B/W Illustrations
    by CRC Press

    Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology.

    The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development.

    The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods.

    The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.

    INTRODUCTION

    Introduction

    Donald R. Mattison

    Visions and Advancements for Meeting the Needs of Safety Assessment of Pharmaceutical and Industrial Chemicals

    Karen A. Augustine-Rauch

    REACH and Environmental Chemicals

    Olivier Taboureau, Karine Audouze, and Søren Brunak

    REPRODUCTION AND DEVELOPMENT: BIOLOGICAL PROCESSES AND ENDPOINTS


    Female Reproductive Physiology

    Mariangela Maluf and Paulo Marcelo Perin

    Maternal Recognition of Pregnancy

    Paulo Marcelo Perin and Mariangela Maluf

    Early Embryo Development and Bipotential Gonad Formation

    Paulo Marcelo Perin and Mariangela Maluf

    Assessing the Reproductive Health of Men with Occupational Exposures

    Steven M. Schrader, Susan Reutman, and Katherine L. Marlow

    REPRODUCTION AND DEVELOPMENT: BIOLOGICAL AND COMPUTATIONAL METHODS


    Animal Study Protocols and Alternative Assays for the Assessment of Reproductive and Developmental Toxicity

    Aldert H. Piersma

    US National Library of Medicine Resources for Computational Toxicology

    Pertti J. Hakkinen

    Modeling Endocrine Regulation of the Menstrual Cycle Using Delay Differential Equations

    Leona A. Harris and James F. Selgrade

    Molecular Structural Characteristics That Influence Partitioning of Xenobiotics into Human Breast Milk

    Snezana Agatonovic-Kustrin and David W. Morton

    Approaches for Pediatric Developmental Drug-Induced Liver Injury

    William F. Salminen and Xi Yang

    Adverse Outcome Pathways for Developmental Toxicity

    Damiano Portinari and Philip N. Judson

    Biography

    Edited by

    Donald R. Mattison, National Institutes of Health, Bethesda, Maryland, USA, and Risk Sciences International, Ottawa, Ontario, Canada