1st Edition

Connective Tissue Histophysiology, Biochemistry, Molecular Biology

    638 Pages 23 Color & 161 B/W Illustrations
    by CRC Press

    638 Pages 23 Color & 161 B/W Illustrations
    by CRC Press

    Connective tissue is a multicomponent, polyfunctional complex of cells and extracellular matrix that serves as a framework for all organs, combining to form a unified organism. It is a structure responsible for numerous vital functions such as tissue–organ integration, morphogenesis, homeostasis maintenance, biomechanical support, and more. The regeneration potential of connective tissue affects healing of damaged tissue and organs, while trauma, stress, and other factors that cause damage to connective tissue can lead to numerous disorders.

    Connective Tissue: Histophysiology, Biochemistry, Molecular Biology brings together crucial knowledge of mammalian connective tissue (including human) and its components, both cellular and noncellular, in one authoritative reference. The breadth and depth of information has fundamental scientific significance as well as applied relevance in clinical medicine. The first half of the book covers the structure, classification, biochemical aspects, histogenesis, and cellular elements of connective tissue. It presents data from the macro- to nanolevel organization of the extracellular matrix—its structural and functional aspects—and addresses metabolic functions and the biochemistry and molecular biology of connective tissue ageing.

    The second half of the book reviews current data on the biochemistry and molecular biology of skeletal connective tissue, including bone and cartilage metabolism and regulation. It presents an in-depth analysis of data on the molecular mechanisms of connective tissue ontogenesis, from embryonic development through ageing. It also reports novel findings on bone marrow stroma and describes electron microscopy results of the nanostructure of bone mineral, mineralized cartilage, and teeth compared with coral and seashells. Comprising both classic and modern data on the histopathology, biochemistry, and molecular biology of connective tissue, this book provides a unique resource for clinicians and researchers alike.

    Peculiarities of Connective Tissue Histophysiology, Biochemistry, and Molecular Biology
    Definitions, Organization Principles, and Classification of Connective Tissue
    Basic Definitions, Principles and Emphasis of Modern Biochemistry and Molecular Biology
    General Biochemical Aspects of Connective Tissue
    Formation and Histogenesis of Connective Tissue
    Embryology and Histogenesis of Connective Tissue
    Molecular and Biochemical Regularities of Initial Stages of Connective Tissue Structures Formation

    Cellular Elements of Connective Tissue
    Proper Cells of Connective Tissue
    Fibroblastic Differon
    Adventitious Cells
    Adipocytes(Lipocytes, Adipocytes)
    Cells Associated with Connective Tissue

    Extracellular Matrix of Connective Tissue: Histophysiology, Biochemistry and Molecular Biology
    Fibrous Structures
    Integrating Buffer Metabolic Medium (Ground Substance) of Connective Tissue Extracellular Matrix
    Basement Membranes
    Interstitial (Interfibrous and Intercellular) Space of Connective Tissue
    Structural Peculiarities of Connective Tissue Various Types and its Organ Specificity
    General Regularities of Molecular and Supramolecular Organization of Connective Tissue Extracellular Matrix. Molecular Mechanisms of Cells and Matrix Interaction
    Catabolism of Extracellular Matrix Macromolecular Components

    Regulation of Connective Tissue Metabolic Functions
    Systemic Factors of Regulation
    Local Factors of Regulation

    Biochemical and Molecular Mechanisms and Manifestations of Connective Tissue Ageing

    Bone – An Organ of the Support and Locomotor Apparatus Containing All Types of Connective Tissue
    Overview of Bone Structure and Function
    General Structural and Functional Characteristics of Bone Components

    Cartilage – Cartilaginous Tissue: Structural, Biochemical and Molecular Biological Characteristics
    Overview of Structure and Composition of Cartilage Tissue
    Hyaline Cartilages – Cartilaginous Tissues
    Elastic Cartilages – Cartilaginous Tissues
    Fibrous Cartilages – Cartilaginous Tissues

    Bone Tissue: The Structural-Functional, Biochemical and Molecular Biological Characteristics of Its Components
    General Overview of Bone Tissue Structure and Composition
    Differons of Bone Cells
    Extracellular Matrix of Bone Tissue
    Interstitial Space of Bone Tissue
    Regulation Mechanisms of Bone Tissue Metabolism and Functions
    Remodeling of Bone Tissue
    Tooth Connective Tissue

    Biochemical Characteristics of Synovial Membrane and Synovia
    Synovial membrane
    Synovia (Synovial Fluid)

    Molecular Biological and Biochemical Regularities of Connective Tissue Structures Ontogenesis
    Molecular Biological and Biochemical Mechanisms of Mesenchyme Condensation. Regulation Systems of Connective Tissue Structure Morphogenesis
    Differentiation of Connective Tissue Cells
    Molecular Biological and Biochemical Regularities of Skeleton Formation and Growth
    Molecular Biological and Biochemical Mechanisms of Joint Formation

    References

    List Abbreviations

    Biography

    Nikolay Petrovich Omeliyanenko, Doctor of Medicine, Professor, Member of the New York Academy of Sciences, Winner of the Prize of the Russian Federation Government, the Chief of the Laboratory of Connective Tissue of the Central Research Institute of Traumatology and Orthopedics of N.N. Priorov, the Department of Public Health of the Russian Federation. The scientific interests: structural and functional organization of bone, cartilaginous tissue and other connective tissue types in health, regeneration and pathology.

    Leonid Ilyich Slutsky, Professor Emeritus, Doctor Habilitatus of Medicine. In 1960–1996 – the Chief of the Laboratory of Biochemistry of the Riga Research Institute of Traumatology and Orthopedics (Latvia). The main scientific interests: biochemistry of the connective tissue and skeleton.

    Sergey Pavlovich Mironov, Doctor of Medicine, Professor, Academician of the Russian Academy of Sciences and Russian Academy of Medical Sciences, Honoured Worker of Science of the Russian Federation, Winner of the State Prize and the Prize of the Russian Federation Government, the Head of the Central Research Institute of Traumatology and Orthopaedics of N.N. Priorov, the Department of Public Health of the Russian Federation. Field of research: clinical and fundamental orthopedics and traumatology.