1st Edition

Signaling Through Cell Adhesion Molecules

By Jun-Lin Guan Copyright 1999

    The field of signal transduction research is one of the fastest growing in all of biomedical research in recent years. Signaling through cell adhesion molecules have long been of interest because of their importance in embryonic development, homeostasis, immune responses, wound healing , and malignant transformation. However, it is only recently realized that cell adhesion molecules are capable of transduce biochemical signals across the plasma membrane to regulate cellular functions.
    Signaling Through Cell Adhesion Molecules brings together novel and current methodology employed in studies of signaling by cell adhesion molecules as presented by leading experts whose research has shaped this nascent area of signal trandsduction research.
    One of the unique features of this method book is its topic-oriented format; experts with "hands-on" experience present various techniques and answers to particular biological questions. Many chapters not only contain the "recipes" on experimental protocols, but also discuss the rationale behind their development.

    Protein-Protein Interactions and Early Events in Integrin Signaling
    The Use of Chimeric Receptors in the Study of Integrin Signaling
    Using Synthetic Peptides to Mimic Integrins: Probing Cytoskeletal Interactions and Signaling Pathways
    Use of the Yeast Two-Hybrid System for the Characterization of Integrin
    Signal Transduction Pathways: Identification of the Integrin-Linked Kinase, p59
    Focal Adhesion Kinase and its Associated Proteins
    Analysis of Paxillin as a Multi-Domain Scaffolding Protein
    p130 in Integrin Signaling
    Specificity of Integrin Signaling
    Late Events and Biological Functions of Integrin Signaling
    Methods for Study of Integrin Regulation of MAP Kinase Cascades
    Methods for Analysis of Adhesion-Dependent Cell Cycle Progression
    Integrin Modulation of Mitogenic Pathways Involved in Muscle Differentiation
    Methods for Studying Anoikis
    Functional Analysis of FAK and Associated Molecules in Cell Migration
    Integrin Signaling in Pericellular Matrix Assembly
    Inside-out Signaling by Integrins
    Studies of Integrin Signaling Through Platelet ab
    Tracking of Integrin-Mediated Adhesion Using Green Fluorescent Protein and Flow Cytometry
    Expression Cloning of Proteins That Modify Integrin Activation
    Regulation of Cell Contractility by RhoA: Stress Fiber and Focal Adhesion Assembly
    Studies of Integrin Signaling Through Platelet General Methods for Studies of Cell Adhesion Molecule-Mediated Signaling
    Intra-and Intercellular Localization of Proteins in Tissue in situ
    Optical Microscopy Studies of (Ca2) Signaling
    Wnt Signaling in Xenopus Embryos


    Biography

    Jun-Lin Guan