360 Pages
by
CRC Press
Also available as eBook on:
Recent research in cell death mechanisms has rekindled interest in PARP's (Poly (ADP-Ribose) Polymerase) intriguing role in necrosis and apoptosis. While the details of how PARP1 functions are still being elucidated, it has tremendous potential as a promising drug target. PARP inhibitors' dual actions of preventing cell death and abating inflammati
PARP in the Nervous System. Role of PARP1 in Neurologic Disorders. The Role of PARP on Safeguarding Genomic Integrity. Functional Testing of Human PARP in Proliferation, Endotoxic Shock and Radiosensitivity. PARP Inhibitors as Neuroprotective Agents for Brain Injury. PARP-Inhibitors and Cardioprotection. Neuroprotection of the Retina with 3-Aminobenzamide, a PARP Inhibitor. PARP Inhibitors and Acute Renal Failure. Role of PARP Activation in the Pathogenesis of Shock and Inflammation. Clinical Development of the Nicotinamides and Benzamides Involving PARP as a Molecular Target. Chemoprotective Effect of a Novel PARP Inhibitor. Beneficial Effect of GPI 6150 Treatment in Multiple Animal Models of Diseases. Protective Effect of PARP Inhibition on UV Light Induced Skin Damage. Role of PARP in the Islet Injury and Vascular Complications Associated with Diabetes Mellitus. ADP-Ribose Polymer Metabolism.
Biography
Jei Zhang
