1st Edition

Cytokine Gene Polymorphisms in Multifactorial Conditions

Edited By Koen Vandenbroeck Copyright 2006
    488 Pages 45 B/W Illustrations
    by CRC Press

    The literature on cytokine genetics is vast, so vast that it is now practically beyond the time or logistical constraints of most scientists to successfully keep pace with it. A compilation of the latest research, Cytokine Gene Polymorphisms in Multifactorial Conditions brings together, reviews, and structures up-to-date information on polymorphisms in cytokine genes. It discusses haplotype structures and linkage disequilibrium patterns in cytokine gene loci; functional biological effects of polymorphisms; and genetic associations with disease. The book documents polymorphisms in the most important cytokine genes, or gene clusters, and their biological and genetic effects in a multitude of distinct multifactorial conditions.

    Unique to this book are the "disease-centered" chapters examining the role of cytokine gene polymorphisms in a multitude of multifactorial conditions. The conditions include autoimmune or chronic inflammatory diseases, cardiovascular disease, infectious diseases, and longevity. "This section is a real tour de force" (Grant Gallagher and Michael F. Seldin, March 2006).

    Broadening the understanding of the effect of genetic variations on human immune responses, the organization, scope, and content of this book make it a valuable and easily accessible resource. The book integrates genetic, immunological, and clinical information and will serve as a reference for novice and expert geneticists, immunologists, cell biologists and clinicians. It is a must for everyone involved in, or planning, cytokine genetics or immunogenetics studies.

    GENERAL CONCEPTS
    The Biology of Cytokines:General Principles, Properties and Lessons from Animal Models, D. Agnello and M. Gadina
    Genetics of Multifactorial Disorders, J.R. Oksenberg and J.D. Rioux
    Statistical Approaches to Analysis of Polymorphisms in Multifactorial Conditions, A. Goris and M. de Andrade
    Introduction to Integrated Bioinformatic Resources for Cytokine Genetics Research, R. Lazarus
    Cytokine Gene Nucleotide Sequence Alignments, J. Bidwell
    SNP Genotyping Techniques, P.-Y. Kwok

    CYTOKINE GENE POLYMORPHISMS
    The IL1 Cluster, T. Pessi, C. Eklund, A. Raitala, and M. Hurme
    IL-2 Biology and Polymorphisms in Multifactorial Conditions, F. Matesanz, M. Fedetz, and A. Alcina
    The Chromosome 5q23.1 -q31.1 Cluster of Cytokines, T. Laitinen
    IL10, R. Lazarus
    The IL19 Subfamily of Cytokines, S. Kõks, K. Kingo, E. Vasar, and H. Silm
    The IFNG -IL26 -IL22 Cytokine Gene Cluster, K. Vandenbroeck and A. Goris
    TNF-a Polymorphisms and Disease, R.M. Gorczynski and I. Boudakov
    Macrophage Migration Inhibitory Factor (MIF), Z. Alourfi, D.W. Ray, and R. Donn
    Polymorphisms of Chemokines and Their Receptors, B. Puissant, C. Combadière, and E. Lavergne

    POLYMORPHIC CYTOKINE NETWORKS IN MULTIFACTORIAL CONDITIONS
    Asthma and Atopy, J. Karjalainen, M. Virta, K. Ädjers, and M. Hurme
    Common Rheumatic Diseases, R. Kilding and A.G. Wilson
    Systemic Lupus Erythematosus, S. D 'Alfonso
    Sjögren 's Syndrome, M. Pertovaara
    Multiple Sclerosis, O.H. Kantarci and B.G. Weinshenker
    Type 1 and 2 Diabetes, R. Bergholdt and F. Pociot
    Psoriasis, S. Kõks, K. Kingo, E. Vasar, and H. Silm
    Diseases of the Gastrointestinal Tract, T. Höhler
    Pulmonary Fibrosis, B. Yucesoy and M.I. Luster
    Atherosclerosis, G. Candore, S. Vasto, G. Colonna-Romano, D. Lio, M. Carusob, I.M. Rea, and C. Caruso
    Longevity, I.M. Rea, G. Candore, L. Cavallone, F. Olivieri, M. Cardelli, C. Franceschi, G. Colonna-Romano, D. Lio, O.A. Ross, and C. Caruso
    AIDS, A. Vasilescu, H. Do, and J.-F. Zagury
    Tropical Infectious Diseases, T. Quirico-Santos, A.M. Da-Cruz, C. Fernandez Kubelka, J. Lannes-Vieira, and M. Ozório Moraes
    Suseptibility to Infection and Severe Disease in Schistosomiasis, V. Arnaud and C. Chevillard
    Index

    Biography

    Koen Vandenbroeck

    "As this volume so capably demonstrates, genetic variation in cytokines, the messengers of the immune system, and their receptors is now recognized as playing an important role in disease susceptibility and outcome...This book is a timely anthology of knowledge, techniques as well as informed speculation…The chapters in this book represent an excellent and timely means of addressing questions related to the study of cytokine gene polymorphisms and will serve as an important reference work.."
    - From the foreword by Grant Gallagher and Michael F. Seldin, Editors, "Genes and Immunity", March 2006