Biomedical Science


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Health Risk Assessment Dermal and Inhalation Exposure and Absorption of Toxicants

Rhoda G.M. Wang, James B. Knaak, Howard I. Maibach
August 29, 2017

Health Risk Assessment is a comprehensive reference focusing on dermal absorption, cholinesterase inhibition, adverse reproductive effects, and carcinogenicity. The book features contributions from over 40 top scientists and covers topics such as PBPK modeling, cytochrome P-450 metabolism in skin,...

Management of Animal Care and Use Programs in Research, Education, and Testing

Robert H. Weichbrod, Gail A. (Heidbrink) Thompson, John N. Norton
August 28, 2017

Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how to work...

Nonclinical Drug Administration: Formulations, Routes and Regimens for Solving Drug Delivery Problems in Animal Model Systems

Shayne C. Gad, Charles B. Spainhour
August 15, 2017

If we will ever achieve Paul Ehrlich’s "magic bullet," that is, a molecule which goes with high selectivity to the therapeutic target site, does what it needs to do, and is subsequently cleared from the body, the practice of safety assessment will have to change. Nonclinical Drug Administration:...

Cellular and Molecular Toxicology and In Vitro Toxicology

Daniel Acosta
July 14, 2017

This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular...

Alcohol and the Gastrointestinal Tract

Victor R. Preedy
July 13, 2017

This book covers all aspects of gastrointestinal tract problems caused by alcohol misuse. Opening chapters discuss epidemiology and the metabolism of alcohol and the liver's role in that process. Alcohol and acetaldehyde dehydrogenases, free radicals, and endocrine changes are discussed in detail....

Alcohol Interactions with Drugs and Chemicals

Edward J. Calabrese
July 13, 2017

Alcohol Interactions with Drugs and Chemicals is a concise volume that identifies, documents, and assesses the capacity of alcohol to alter the toxicity of chemical pollutants and drugs in animal models and humans. The book systematically assesses interactions according to general chemical classes...

Benzene Carcinogenicity

Muzaffer Aksoy
July 13, 2017

An in-depth exploration of Benzene Carcinogenicity including source, measurement, analysis, and clinical conclusions....

Biological Effects of Low Level Exposures to Chemical and Radiation

Edward J. Calabrese
July 13, 2017

This book features papers presented at a workshop discussing current knowledge about the biological effects of low level exposures (BELLE). The book is designed to help establish a scientific base for future BELLE initiatives and is focused on the issue of the toxicological implications of...

Asbestos: Risk Assessment, Epidemiology, and Health Effects, Second Edition

Ronald F. Dodson, Samuel P. Hammar
April 06, 2017

The first edition of Asbestos: Risk Assessment, Epidemiology, and Health Effects received critical acclaim due to the interdisciplinary nature of its content. Editors Ronald Dodson and Samuel Hammar have carefully kept this popular focus while updating and expanding the topics covered in the first...

Handbook of Metal-Microbe Interactions and Bioremediation

Surajit Das, Hirak Ranjan Dash
March 23, 2017

Around the World, metal pollution is a major problem. Conventional practices of toxic metal removal can be ineffective and/or expensive, delaying and exacerbating the crisis. Those communities dealing with contamination must be aware of the fundamentals advances of microbe-mediated metal removal...

Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition

David Woolley, Adam Woolley
March 07, 2017

Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition shows how to conduct a program of safety evaluation and testing and then to interpret and apply the resulting data and information in the real world, beginning with the basic concepts in toxicology and progressing to the...

Neural Cell Biology

Cheng Wang, William Slikker, Jr.
February 13, 2017

This book delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text reviews and discusses approaches that can be used as effective tools to dissect mechanisms...