Biomedical Science

Pharmacology

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Kratom and Other Mitragynines: The Chemistry and Pharmacology of Opioids from a Non-Opium Source

Robert B. Raffa
October 29, 2014

Opioids such as morphine, codeine, and oxycodone are extracts or analogs isolated from a single source: the opium poppy. For a long time, it was believed to be nature’s only source of opioids. But it now appears that biological diversity has evolved an alternative source of opioid compounds—those...

Re-inventing Drug Development

Jeffrey S. Handen
October 28, 2014

The biopharmaceutical industry has entered an era of unprecedented change and challenge, characterized by increasing pricing pressures, rising rates of attrition in the product development lifecycle, and decreasing scientific innovation. The most successful products are losing patent protection,...

Nutrition and Epigenetics

Emily Ho, Frederick Domann
October 16, 2014

Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and...

Drug Delivery and Development of Anti-HIV Microbicides

José das Neves, Bruno Sarmento
October 16, 2014

The worldwide impact of HIV/AIDS is well recognized. This book provides for the first time a thorough and critical overview of current aspects, recent developments, and trends in the formulation and drug delivery concerning anti-HIV microbicides by leading scientists in the field. Additionally,...

Melatonin: Therapeutic Value and Neuroprotection

Venkatramanujan Srinivasan, Gabriella Gobbi, Samuel D. Shillcutt, Sibel Suzen
October 15, 2014

There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic potential of melatonin...

Natural Products Chemistry: Sources, Separations and Structures

Raymond Cooper, George Nicola
July 29, 2014

Notoriously cumbersome to isolate and challenging to synthesize, the path of natural products to viable drugs is an arduous journey. Yet compounds isolated from nature may possess fascinating structures, biological profiles and pharmaceutical potential far greater than anything made by man....

Hormesis in Health and Disease

Suresh I. S. Rattan, Éric Le Bourg
May 16, 2014

Some mild stresses have positive effects on survival and aging as shown in animal models. There is also a large body of research that demonstrates these hormetic effects on aging, health, and resistance to severe stresses and diseases in human beings. However, the data are dispersed in the...

Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, Third Edition

Luis M. Botana
March 12, 2014

The last few years have brought about many changes in the field of marine and freshwater toxins, with advances in analytical technology and the realization that these toxins are a global issue. Offering a complete reference guide, Seafood and Freshwater Toxins: Pharmacology, Physiology, and...

FDA Regulatory Affairs: Third Edition

David Mantus, Douglas J. Pisano
February 28, 2014

FDA Regulatory Affairs is a roadmap to prescription drug, biologics, and medical device development in the United States. Written in plain English, the concise and jargon-free text demystifies the inner workings of the US Food and Drug Administration (FDA) and facilitates an understanding of how...

Experiments in Pharmaceutical Chemistry, Second Edition

Charles Dickson
February 21, 2014

Written by an author with more than 40 years of teaching experience in the field, Experiments in Pharmaceutical Chemistry, Second Edition responds to a critical classroom need for material on directed laboratory investigations in biological and pharmaceutical chemistry. This new edition supplies 75...

Freshwater Phytopharmaceutical Compounds

Santhanam Ramesh, Rajabalaya Rajan, Ramasamy Santhanam
August 28, 2013

Herbal medicines have been used as prophylactic measures and curative treatments throughout human history, and crude herbal extracts are commonly used in pharmaceutical research. Producing a variety of structurally novel bioactive compounds or secondary metabolites, freshwater plants provide a...

Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds

Goutam Brahmachari
February 20, 2013

Natural products play crucial roles in modern drug development, and constitute a prolific source of novel lead compounds or pharmacophores for ongoing drug discovery programs. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds presents cutting-edge research in the chemistry of...

Conferences

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