Biomedical Science


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Biosimilars and Interchangeable Biologics: Strategic Elements

Sarfaraz K. Niazi
July 26, 2017

What’s the Deal with Biosimilars? Biosimilars are gaining momentum as new protein therapeutic candidates that can help fill a vital need in the healthcare industry. The biological drugs are produced by recombinant DNA technology that allows for large-scale production and an overall reduction time...

In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications

Claudio N. Cavasotto
July 26, 2017

In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design. Its main aims are to introduce the theoretical framework and algorithms,...

Targeted Delivery of Small and Macromolecular Drugs

Ajit S. Narang, Ram I. Mahato
July 26, 2017

Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Focusing on the delivery...

CRC Handbook of Eicosanoids, Volume II: Prostaglandins and Related Lipids

A. L. Willis
July 13, 2017

Building upon the extensive compilation of biochemical data featured in Volume I of the Handbook of Eicosanoids, the new Volume II describes the past, present, and potential future impact of eicosanoid research on new drug development. The reader is taken from a historical perspective through...

Delivery Strategies for Antisense Oligonucleotide Therapeutics

Saghir Akhtar
July 13, 2017

With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific...

Drug Delivery: An Integrated Clinical and Engineering Approach

Yitzhak Rosen, Pablo Gurman, Noel Elman
July 07, 2017

Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for...

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring

Amitava Dasgupta
June 16, 2017

For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder...

In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development

Dhanya Sunil, Pooja R Kamath, Raghu Chandrashekhar H
May 01, 2017

This comprehensive and useful handbook represents a definitive up-to-date compendium of key in vitro bioassay methods that are employed to quantify and validate the anticancer activity of a drug candidate before it makes its way in to animal or clinical trials. In Vitro Bioassay Techniques for...

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Fifth Edition

Johan Gabrielsson, Daniel Weiner
January 26, 2017

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications teaches everyday biological data analysis to the undergraduate and graduate levels. Through numerous examples and over 100 tutorials, scientists learn how to use PK/PD seamlessly in a variety of practical areas, from...

Biosimilar Clinical Development: Scientific Considerations and New Methodologies

Kerry B. Barker, Sandeep M. Menon, Ralph B. D'Agostino, Sr., Siyan Xu, Bo Jin, PhD
January 17, 2017

Biosimilars have the potential to change the way we think about, identify, and manage health problems. They are already impacting both clinical research and patient care, and this impact will only grow as our understanding and technologies improve. Written by a team of experienced specialists in...

Advances in Pulmonary Drug Delivery

Philip Chi Lip Kwok, Hak-Kim Chan
December 20, 2016

The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and...

Rare Earth Elements in Human and Environmental Health: At the Crossroads Between Toxicity and Safety

Giovanni Pagano
November 11, 2016

This book presents the multifaceted aspects of rare earth elements (REEs), focusing on both their potential benefits and adverse health effects. The adverse impacts of REEs on human and environmental health raise a growing concern not only in the scientific community but also among a number of...