Biomedical Science


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Group Sequential Methods with Applications to Clinical Trials

Christopher Jennison, Bruce W. Turnbull
September 15, 1999

Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early...

Comparative Qsar

James Devillers
March 03, 1998

As the 21st century approaches, there is little doubt that the tools and resources are available to unlock all the secrets of Quantitative Structure-Activity Relationships (QSAR) in order to design more efficient drugs and safer chemicals. The comparison QSAR models provide are a key to reach a...

Tables for the Use of Range and Studentized Range in Tests of Hypotheses

H. Leon Harter, N. Balakrishnan
October 27, 1997

A companion volume to the authors' previous well-received work, the CRC Handbook of Tables for the Use of Order Statistics in Estimation, this handbook discusses testing whether a hypothesis is true or false. Together, these volumes are your complete reference to theory and important tables...

Analysis of Incomplete Multivariate Data

J.L. Schafer
August 01, 1997

The last two decades have seen enormous developments in statistical methods for incomplete data. The EM algorithm and its extensions, multiple imputation, and Markov Chain Monte Carlo provide a set of flexible and reliable tools from inference in large classes of missing-data problems. Yet, in...

Bayesian Methods for Finite Population Sampling

Malay Ghosh, Glen Meeden
June 01, 1997

Assuming a basic knowledge of the frequentist approach to finite population sampling, Bayesian Methods for Finite Population Sampling describes Bayesian and predictive approaches to inferential problems with an emphasis on the likelihood principle. The authors demonstrate that a variety of levels...

A Course in Large Sample Theory

Thomas S. Ferguson
July 01, 1996

A Course in Large Sample Theory is presented in four parts. The first treats basic probabilistic notions, the second features the basic statistical tools for expanding the theory, the third contains special topics as applications of the general theory, and the fourth covers more standard...

Clinical Trials: An Introduction

Ann Raven, Frank Wells
October 01, 1993

This volume provides an introduction to the process of clinical drug development. It demystifies the way new medicines are discovered, tested and regulated. This book is intended for those who wich to understand the background of clinical trials from a pharmaceutical company perspective, and is...

Biostatistics for Epidemiologists

Anders Ahlbom
March 25, 1993

Biostatistics for Epidemiologists is a unique book that provides a collection of methods that can be used to analyze data in most epidemiological studies. It examines the theoretical background of the methods described and discusses general principles that apply to the analysis of epidemiological...

Practical Handbook of Sample Size Guidelines for Clinical Trials

Jonathan J. Shuster
November 30, 1992

Practical Handbook of Sample Size Guidelines for Clinical Trials is a concise guide and powerful software utility program that provides a valuable, non-technical blueprint for the design and analysis of survival clinical trials. This text and software allow clinical researchers to write more...

Practical Statistics for Medical Research

Douglas G. Altman
November 22, 1990

Most medical researchers, whether clinical or non-clinical, receive some background in statistics as undergraduates. However, it is most often brief, a long time ago, and largely forgotten by the time it is needed. Furthermore, many introductory texts fall short of adequately explaining the...

Health Research Design and Methodology

Eucharia E. Nnadi-Okolo
August 27, 1990