Biomedical Science


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Regression Models as a Tool in Medical Research

Werner Vach
November 27, 2012

While regression models have become standard tools in medical research, understanding how to properly apply the models and interpret the results is often challenging for beginners. Regression Models as a Tool in Medical Research presents the fundamental concepts and important aspects of regression...

Bayesian Methods in Health Economics

Gianluca Baio
November 12, 2012

Health economics is concerned with the study of the cost-effectiveness of health care interventions. This book provides an overview of Bayesian methods for the analysis of health economic data. After an introduction to the basic economic concepts and methods of evaluation, it presents Bayesian...

Applied Medical Statistics Using SAS

Geoff Der, Brian S. Everitt
October 01, 2012

Written with medical statisticians and medical researchers in mind, this intermediate-level reference explores the use of SAS for analyzing medical data. Applied Medical Statistics Using SAS covers the whole range of modern statistical methods used in the analysis of medical data, including...

Medical Biostatistics, Third Edition

Abhaya Indrayan
August 07, 2012

Encyclopedic in breadth, yet practical and concise, Medical Biostatistics, Third Edition focuses on the statistical aspects of medicine with a medical perspective, showing the utility of biostatistics as a tool to manage many medical uncertainties. The author concludes "Just as results of medical...

The A-Z of Error-Free Research

Phillip I. Good
August 01, 2012

A Practical Guide with Step-by-Step Explanations, Numerous Worked Examples, and R CodeThe A–Z of Error-Free Research describes the design, analysis, modeling, and reporting of experiments, clinical trials, and surveys. The book shows you when to use statistics, the best ways to cope with variation,...

Design and Analysis of Bridging Studies

Jen-pei Liu, Shein-Chung Chow, Chin-Fu Hsiao
July 26, 2012

As the development of medicines has become more globalized, the geographic variations in the efficacy and safety of pharmaceutical products need to be addressed. To accelerate the product development process and shorten approval time, researchers are beginning to design multiregional trials that...

Interval-Censored Time-to-Event Data: Methods and Applications

Ding-Geng (Din) Chen, Jianguo Sun, Karl E. Peace
July 19, 2012

Interval-Censored Time-to-Event Data: Methods and Applications collects the most recent techniques, models, and computational tools for interval-censored time-to-event data. Top biostatisticians from academia, biopharmaceutical industries, and government agencies discuss how these advances are...

Randomized Clinical Trials of Nonpharmacological Treatments

Isabelle Boutron, Philippe Ravaud, David Moher
December 19, 2011

Nonpharmacological treatments include a wide variety of treatments such as surgery, technical procedures, implantable and non-implantable devices, rehabilitation, psychotherapy, and behavioral interventions. Unlike pharmacological treatments, these have no specific requirements for approval....

Adaptive Design Methods in Clinical Trials, Second Edition

Shein-Chung Chow, Mark Chang
December 01, 2011

With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA’s recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and...

Adaptive and Flexible Clinical Trials

Richard Chin
August 25, 2011

Adaptive clinical trial designs, unlike traditional fixed clinical trial designs, enable modification of studies in response to the data generated in the course of the trial. This often results in studies that are substantially faster, more efficient, and more powerful. Recent developments in...

Flexible Parametric Survival Analysis Using Stata: Beyond the Cox Model

Patrick Royston, Paul C. Lambert
August 04, 2011

Through real-world case studies, this book shows how to use Stata to estimate a class of flexible parametric survival models. It discusses the modeling of time-dependent and continuous covariates and looks at how relative survival can be used to measure mortality associated with a particular...

Design and Analysis of Non-Inferiority Trials

Mark D. Rothmann, Brian L. Wiens, Ivan S.F. Chan
July 12, 2011

The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Using examples from real clinical trials, Design and Analysis of Non-Inferiority Trials brings together this body of research and confronts the...