Biomedical Science

Biostatistics

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Statistical Methods for Drug Safety

Robert D. Gibbons, Anup Amatya
July 21, 2015

Explore Important Tools for High-Quality Work in Pharmaceutical Safety Statistical Methods for Drug Safety presents a wide variety of statistical approaches for analyzing pharmacoepidemiologic data. It covers both commonly used techniques, such as proportional reporting ratios for the analysis of...

Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects

Oleksandr Sverdlov
June 30, 2015

Is adaptive randomization always better than traditional fixed-schedule randomization? Which procedures should be used and under which circumstances? What special considerations are required for adaptive randomized trials? What kind of statistical inference should be used to achieve valid and...

Empirical Likelihood Method in Survival Analysis

Mai Zhou
June 18, 2015

Add the Empirical Likelihood to Your Nonparametric Toolbox Empirical Likelihood Method in Survival Analysis explains how to use the empirical likelihood method for right censored survival data. The author uses R for calculating empirical likelihood and includes many worked out examples with the...

Introductory Adaptive Trial Designs: A Practical Guide with R

Mark Chang
June 08, 2015

All the Essentials to Start Using Adaptive Designs in No Time Compared to traditional clinical trial designs, adaptive designs often lead to increased success rates in drug development at reduced costs and time. Introductory Adaptive Trial Designs: A Practical Guide with R motivates newcomers to...

Health Technology Assessment: Using Biostatistics to Break the Barriers of Adopting New Medicines

Robert B. Hopkins, MA, MBA, PhD, Ron Goeree, MA
April 10, 2015

The term health technology refers to drugs, devices, and programs that can improve and extend quality of life. As decision-makers struggle to find ways to reduce costs while improving health care delivery, health technology assessments (HTA) provide the evidence required to make better-informed...

Introductory Statistics for the Health Sciences

Lise DeShea, Larry E. Toothaker
March 23, 2015

Introductory Statistics for the Health Sciences takes students on a journey to a wilderness where science explores the unknown, providing students with a strong, practical foundation in statistics. Using a color format throughout, the book contains engaging figures that illustrate real data sets...

Design and Analysis of Clinical Trials for Predictive Medicine

Shigeyuki Matsui, Marc Buyse, Richard Simon
March 19, 2015

Design and Analysis of Clinical Trials for Predictive Medicine provides statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics—from identifying...

Inference Principles for Biostatisticians

Ian C. Marschner
December 11, 2014

Designed for students training to become biostatisticians as well as practicing biostatisticians, Inference Principles for Biostatisticians presents the theoretical and conceptual foundations of biostatistics. It covers the theoretical underpinnings essential to understanding subsequent core...

Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research

Chul Ahn, Moonseoung Heo, Song Zhang
December 09, 2014

Accurate sample size calculation ensures that clinical studies have adequate power to detect clinically meaningful effects. This results in the efficient use of resources and avoids exposing a disproportionate number of patients to experimental treatments caused by an overpowered study. Sample...

Modelling Survival Data in Medical Research, Third Edition

David Collett
December 04, 2014

Modelling Survival Data in Medical Research describes the modelling approach to the analysis of survival data using a wide range of examples from biomedical research. Well known for its nontechnical style, this third edition contains new chapters on frailty models and their applications, competing...

Noninferiority Testing in Clinical Trials: Issues and Challenges

Tie-Hua Ng
December 01, 2014

Take Your NI Trial to the Next Level Reflecting the vast research on noninferiority (NI) designs from the past 15 years, Noninferiority Testing in Clinical Trials: Issues and Challenges explains how to choose the NI margin as a small fraction of the therapeutic effect of the active control in a...

Clinical Trial Biostatistics and Biopharmaceutical Applications

Walter R. Young, Ding-Geng (Din) Chen
November 20, 2014

Since 1945, "The Annual Deming Conference on Applied Statistics" has been an important event in the statistics profession. In Clinical Trial Biostatistics and Biopharmaceutical Applications, prominent speakers from past Deming conferences present novel biostatistical methodologies in clinical...

Conferences

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