Biomedical Science


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Combinatorial Pattern Matching Algorithms in Computational Biology Using Perl and R

Gabriel Valiente
June 14, 2017

Emphasizing the search for patterns within and between biological sequences, trees, and graphs, Combinatorial Pattern Matching Algorithms in Computational Biology Using Perl and R shows how combinatorial pattern matching algorithms can solve computational biology problems that arise in the analysis...

Microarray Image Analysis: An Algorithmic Approach

Karl Fraser, Zidong Wang, Xiaohui Liu
June 14, 2017

To harness the high-throughput potential of DNA microarray technology, it is crucial that the analysis stages of the process are decoupled from the requirements of operator assistance. Microarray Image Analysis: An Algorithmic Approach presents an automatic system for microarray image processing to...

Cancer Systems Biology

Edwin Wang
June 14, 2017

The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation methods to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorigenesis,...

Biological Sequence Analysis Using the SeqAn C++ Library

Andreas Gogol-Döring, Knut Reinert
June 14, 2017

An Easy-to-Use Research Tool for Algorithm Testing and Development Before the SeqAn project, there was clearly a lack of available implementations in sequence analysis, even for standard tasks. Implementations of needed algorithmic components were either unavailable or hard to access in third-party...

Biological Data Mining

Jake Y. Chen, Stefano Lonardi
June 07, 2017

Like a data-guzzling turbo engine, advanced data mining has been powering post-genome biological studies for two decades. Reflecting this growth, Biological Data Mining presents comprehensive data mining concepts, theories, and applications in current biological and medical research. Each chapter...

Systems Biology and Bioinformatics: A Computational Approach

Kayvan Najarian, Siamak Najarian, Shahriar Gharibzadeh, Christopher N. Eichelberger
May 31, 2017

The availability of molecular imaging and measurement systems enables today’s biologists to swiftly monitor thousands of genes involved in a host of diseases, a critical factor in specialized drug development. Systems Biology and Bioinformatics: A Computational Approach provides students with a...

Algorithms for Next-Generation Sequencing

Wing-Kin Sung
May 24, 2017

Advances in sequencing technology have allowed scientists to study the human genome in greater depth and on a larger scale than ever before – as many as hundreds of millions of short reads in the course of a few days. But what are the best ways to deal with this flood of data? Algorithms for...

Computational Protein-Protein Interactions

Ruth Nussinov, Gideon Schreiber
May 22, 2017

Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available,...

Introduction to Integrative Engineering: A Computational Approach to Biomedical Problems

Guigen Zhang
March 01, 2017

This textbook is designed for an introductory course at undergraduate and graduate levels for bioengineering students. It provides a systematic way of examining bioengineering problems in a multidisciplinary computational approach. The book introduces basic concepts of multidiscipline-based...

Statistical Modeling and Machine Learning for Molecular Biology

Alan Moses
December 15, 2016

Molecular biologists are performing increasingly large and complicated experiments, but often have little background in data analysis. The book is devoted to teaching the statistical and computational techniques molecular biologists need to analyze their data. It explains the big-picture concepts...

Data Analysis for the Life Sciences with R

Rafael A. Irizarry, Michael I. Love
August 10, 2016

This book covers several of the statistical concepts and data analytic skills needed to succeed in data-driven life science research. The authors proceed from relatively basic concepts related to computed p-values to advanced topics related to analyzing highthroughput data. They include the R code...

Computational Biology and Bioinformatics: Gene Regulation

Ka-Chun Wong
May 09, 2016

The advances in biotechnology such as the next generation sequencing technologies are occurring at breathtaking speed. Advances and breakthroughs give competitive advantages to those who are prepared. However, the driving force behind the positive competition is not only limited to the...