Biomedical Science

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Cytochrome P450 2D6: Structure, Function, Regulation and Polymorphism


Shufeng Zhou
March 9, 2016

Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic pathways and are classified in various superfamilies. The CYP, or P450, superfamily accounts for 90% of the oxidative metabolism of clinical drugs. One member of this superfamily, P450 2D6 (or CYP2D6), singleh...

Behavioral Neuroendocrinology

Barry R. Komisaruk, Gabriela González-Mariscal
February 16, 2017

Inspired by Carlos Beyer’s 50 years of pioneering research and influence on his students and colleagues, Behavioral Neuroendocrinology builds upon Beyer’s fundamental discoveries and concepts as well as their widespread implications. It presents original research and reviews on mechanisms — genomic...

Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials

Toshiro Tango
February 16, 2017

Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials is the first book focused on the application of generalized linear mixed models and its related models in the statistical design and analysis of repeated measures from randomized controlled trials. The...

Autism Imaging and Devices

Manuel F. Casanova, Ayman El-Baz, Jasjit S. Suri
February 15, 2017

This book covers state-of-the-art medical image analysis approaches currently pursued in autism research. Chapters cover recent advances in diagnosis using structural neuroimaging. All aspects of imaging are included, such as electrophysiology (EEG, ERP, QEEG, and MEG), postmortem techniques, and...

Exercise and Mental Health: Neurobiological Mechanisms

Henning Budde, Mirko Wegner
February 15, 2017

Every fourth person in North America and Europe experiences at least one episode of depression or anxiety disorder over their lifetimes. Research on the impact of exercise on depression, anxiety, and well-being illustrates a positive effect on various measures of mental health by inducing the same...

Neural Cell Biology

Cheng Wang, William Slikker, Jr.
February 13, 2017

This book delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text reviews and discusses approaches that can be used as effective tools to dissect mechanisms...

Physics of PET and SPECT Imaging

Magnus Dahlbom
February 09, 2017

PET and SPECT imaging has improved to such a level that they are opening up exciting new horizons in medical diagnosis and treatment. This book provides a complete introduction to fundamentals and the latest progress in the field, including an overview of new scintillator materials and innovations...

Methods in Comparative Effectiveness Research

Constantine Gatsonis, Sally C. Morton
February 07, 2017

Comparative effectiveness research (CER) is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care (IOM 2009). CER is conducted to develop evidence that...

ISO 9001: 2015 - A Complete Guide to Quality Management Systems

Itay Abuhav
February 07, 2017

This book covers all of the new ISO 9001 requirements in detail, including examples and demonstrations from various fields and industries. In the practice of industry, the changes will demand from the ISO 9001 standard certified organizations to initiate massive adjustments to their quality...

Imaging in Photodynamic Therapy

Michael R. Hamblin, Yingying Huang
February 01, 2017

This book covers the broad field of cellular, molecular, preclinical, and clinical imaging either associated with or combined with photodynamic therapy (PDT). It showcases how this approach is used clinically for cancer, infections, and diseases characterized by unwanted tissue such as...

Robotic Assistive Technologies: Principles and Practice

Pedro Encarnação, Albert Cook
January 31, 2017

This book contains a comprehensive overview of all current uses of robots in rehabilitation. The underlying principles in each application are provided. This is followed by a critical review of the technology available, of the utilization protocols, and of user studies, outcomes, and clinical...

Immunoassays: Development, Applications and Future Trends

Richard O'Kennedy, Caroline Murphy
January 31, 2017

The concept behind this book is to provide a detailed and practical overview of the development and use of immunoassays in many different areas. Immunoassays are analytical tests that utilise antibodies to measure the amount, activity or identity of an analyte. This book is designed to provide a...

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Fifth Edition

Johan Gabrielsson, Daniel Weiner
January 26, 2017

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications teaches everyday biological data analysis to the undergraduate and graduate levels. Through numerous examples and over 100 tutorials, scientists learn how to use PK/PD seamlessly in a variety of practical areas, from...