Huiliang Cao
Cao focuses on exploring the cellular responses to materials engineered with distinctive surface or interface properties, especially developing antibacterial thin films or coatings which favor the functions of mammalian cells.
Subjects: Biomedical Science
Biography
Oct.2012- Current, Associate Professor, Shanghai Institute of Ceramics, Chinese Academy of SciencesDec.2010-Oct.2012, Assistant Professor, Shanghai Institute of Ceramics, Chinese Academy of Sciences
Feb. 2009-Dec. 2010, Postdoctoral Fellow, Biomaterials and Tissue Engineering Research Center,
Shanghai Institute of Ceramics, Chinese Academy of Sciences
Jul. 2008-Feb. 2009, Lecturer at Nanchang Hangkong University
Jul. 2003-Jun. 2008, Study of material science, South China University of Technology
Sept.1999-Jul. 2003, Study of material science, Nanchang Institute of Aeronautical Technology
Education
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Bachelor Degree, NIAT, China
Doctoral Degree, SCUT, China
Areas of Research / Professional Expertise
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Surface modification of biomaterials.
Personal Interests
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Plasma ion implantation; Micro-arc oxidation
Books
Articles
Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles
Published: Jan 23, 2017 by ACS Appl Mater Interfaces. 2017, 9:5149-5157
Authors: Huiliang Cao, Wenjie Zhang, Fanhao Meng, Jinshu Guo, Donghui Wang, Shi Qian, Xinquan Jiang, Xuanyong Liu, Paul K. Chu
Silver nanoparticles (Ag NPs) with diameters ranging from 4 to 19 nm were in situ fabricated and immobilized on titanium by using a plasma immersion ion implantation process. The particles have a population-dependent capability in activating the integrin α5 orchestrated MAPK/ERK signal cascade of osteoblast differentiation in rat bone marrow stem cells (BMSCs), and promoting osteointegration of titanium.
Nano-thick calcium oxide armed titanium: boosts bone cells against MRSA
Published: Feb 22, 2016 by Scientific Reports
Authors: Huiliang Cao, Hui Qin, Yaochao Zhao, Guodong Jin, Tao Lu, Fanhao Meng, Xianlong Zhang, Xuanyong Liu
It demonstrated that titanium armed with a nano-thick calcium oxide layer was effective on averting methicillin-resistant Staphylococcus aureus (MRSA) infections in rabbits. This study demonstrated for the first time that calcium, as one of the major elements in a human body, could be engineered to avert MRSA infections, which is promising as a safe precaution of disinfection for implantable biomedical devices.
Spacing-Dependent Antimicrobial Efficacy of Immobilized Silver Nanoparticles
Published: Feb 04, 2014 by J. Phys. Chem. Lett. 2014, 5, 743−748
Authors: Huiliang Cao, Yuqin Qiao, Fanhao Meng, Xuanyong Liu
Silver nanoparticles with a similar mean particle diameter (∼5.0nm) but distinguished dispersion densities were in situ fabricated and immobilized onplasma-sprayed titanium oxide coatings by a silver plasma immersion ion implantation process. Experiments and theoretical predictions demonstrated that the efficacy of these Ag NPs against bacteria relies on their electron storage capability, which is the interparticle distance associated in the dark, and it is inversely dose-dependent.
Electron storage mediated dark antibacterial action of bound silver nanoparticle
Published: Oct 17, 2012 by Acta Biomaterialia 9 (2013) 5100–5110
Authors: Huiliang Cao, Yuqin Qiao, Xuanyong Liu, Tao Lu, Ting Cui, Fanhao Meng, Paul K. Chu
Size tunable silver nanoparticles are synthesized and incorporated into titanium oxide coatings (TOCs) by manipulating the atomic-scale heating effect of silver plasma immersion ion implantation (Ag PIII). The resulting Ag NPs/TOC composite coatings possess electron storage capability that gives rise to both controlled antibacterial activity and excellent compatibility with mammalian cells.
Biological actions of silver nanoparticles embedded in titanium controlled by ..
Published: Oct 20, 2010 by Biomaterials 32 (2011) 693-705
Authors: Huiliang Cao, Xuanyong Liu, Fanhao Meng, Paul K. Chu
Titanium embedded with silver nanoparticles using a single step silver plasma immersion ion implantation demonstrate micro-galvanic effects that give rise to both controlled antibacterial activity and excellent compatibility with osteoblasts.