Vitamin A in Health and Disease

1st Edition

Rune Blomhoff

CRC Press
Published February 1, 1994
Reference - 704 Pages
ISBN 9780824791209 - CAT# DK4918
Series: Antioxidants in Health and Disease

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Table of Contents


Overview of Vitamin A Metabolism and Function

Metabolism of Vitamin A

Absorption of Vitamin A
Role of Perisinusoidal Stellate Cells in Vitamin A Storage
The Retinol-Binding Protein Superfamily
Dynamic and Control of Plasma Retinol
Retinoic Acid Homeostasis: Prospective Roles of b-Carotene, Retinol, CRBP, and CRABP

Mechanism of Action of Vitamin A and Carotenoids

Role of Nuclear Retinoic Acid Receptors in the Regulation of Gene Expression
The Retinoid X Receptors: Modulators of Multiple Hormonal Signaling Pathways
Retinoylation of Proteins in Mammalian Cells
Role of Carotenoids in Antioxidant Defense

Embryonic Development

Role of Retinoids in Embryonic Development
Vitamin A in Lung Development and Bronchopulmonary Dysplasia
Are Ethanol-Induced Birth Defects Caused by Functional Retinoic Acid Deficiency?

Skin and Epithelial Cells

Role of Retinoids in Normal and Diseased Skin
Regulation of Epithelial Differentiation by Retinoids

Blood Cells

Role of Retinoids in Normal Hematopoiesis and the Immune System
Retinoids and Acute Myeloid Leukemia


Retinoid Isomerization Reactions in the Visual System


Vitamin A Functions in the Reproductive Organs

Intake and Cancer Incidence

Vitamin A and Cancer: Epidemiological Evidence in Humans

Deficiency and Toxicity

Vitamin A Deficiency: Its Epidemiology and Relation to Child Mortality and Morbidity
Teratogenicity of Vitamin A and Retinoids


Dietary Vitamin A Requirements

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