Understanding Autism: From Basic Neuroscience to Treatment

Steven O. Moldin, John L R Rubenstein

April 25, 2006 by CRC Press
Reference - 552 Pages - 18 Color & 54 B/W Illustrations
ISBN 9780849327322 - CAT# 2732

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  • Covers genetic and genomic technologies currently used to dissect the molecular basis of autism
  • Provides an exhaustive review of cytogenetic, linkage, association, candidate gene, and genetic mapping studies
  • Describes new approaches to the analysis of gene expression and the extension of current studies to include endophenotypes in families of autistic probands
  • Examines the potential role of epigenetic mechanisms in the etiology of autism through the regulation of gene expression by mechanisms that do not alter gene sequences
  • Includes current clinical findings that focus on neuroanatomy and neurochemistry, functional neuroimaging, structural neuroimaging, and neurophysiology and neuropsychology
  • Includes a theoretical and methodological outline of how to identify the public health costs of autism
  • Summary

    Taking an all-inclusive look at the subject, Understanding Autism: From Basic Neuroscience to Treatment reviews state-of-the-art research on the diagnosis, treatment, and prevention of autism. The book addresses potential mechanisms that may underlie the development of autism and the neural systems that are likely to be affected by these molecular, genetic, and infectious etiologies. It reviews key findings that inform diagnosis, epidemiology, clinical neuroscience, and treatment.

    The book concludes with a discussion of the economic cost of autism and provides a biomedical and public health perspective of the impact of this devastating disease. With chapters authored by clinical and basic researchers at the forefront of molecular and systems neuroscience, clinical neuroscience, and health economics, the book presents a powerful and comprehensive synthesis of current research on autism and its underlying neural substrates. The book's two editors are considered elite pioneers in this area of research. Dr. Rubenstein was recently elected to the highly prestigious Institute of the Medicine, an honor reserved for those most committed to professional achievement and public service.


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