M. tuberculosis remains one of the most successful human pathogens known. The causative agent of tuberculosis, it also has a unique ability to persist for years in the infected, apparently healthy host. This dormant organism can be reactivated years, even decades later to cause tuberculosis. Knowledge regarding the interaction of M. tuberculosis with the host is fundamental to understanding the pathogenesis, leading eventually to the development of strategies for the prevention and control of infection and disease.
By integrating genetic, microbiologic, immunologic, and cell biologic approaches to elucidate pathogenesis, penetrating new insights into the interaction of M. tuberculosis with the host have emerged. This book reviews the most important state-of-the-art approaches currently used to study microbe-host interactions and highlights emerging methodologies. Strategies to analyze the following topics are included: mycobacterial entry, growth, and gene expression in macrophages; analysis of post-phagocytic events; analysis of signaling in infected macrophage; the acquired immune response; newer animal- and non animal-models systems; latency; and the epidemiology of M. tuberculosis infections.
Table of Contents
1. Mycobacterial Entry and Growth Using In Vitro Macrophage Models. 2. Analysis of Post-Phagocytic Events. 3. Analysis of Macrophage Signaling Following M. tuberculosis Infection. 4. The Acquired Immune Response to M. tuberculosis. 5. New In Vitro Models of Mycobacterial Pathogenesis. 6. Animal Models in the Analysis of Pathogenesis. 7. Analysis of Mycobacterium Tuberculosis Gene Expression in the Human Host. 8. Analysis of Latency. 9. Molecular Epidemiology: Clinical Utility, Public Health Implication, and Relevance to Pathogenesis.
This book provided chapters that are relevant to the subject and contain a balance between literature review, technical description and interpretation of results. Individual chapters are well written and easy to read.
This book is highly recommended to individuals who wish to update themselves on current methods and research in tuberculosis host pathogen interactions. - Microbiology Today (May 2004)
Tuberculosis: The Microbe Host Interface...provide a state-of-the-art study of two human pathogens by integrating genetic, microbiogical, and immunological approaches to eludicate the mechanisms of pathogenesis. At the same time...offering interesting reading for microbiologists, molecular biologists, and clinicians. - Int. Microbiology (Vol. 7, 2004)