1st Edition
Trends and Future Perspectives in Peptide and Protein Drug Delivery
Peptide and protein drug delivery research has been moving at a brisk pace for over 10 years. This is the fourth volume in the Drug Targeting and Delivery book series is a collection of selected snapshots of the major past and future developments in this exciting field as seen by over 20 invited speakers at a three-day conference on protein drug delivery held on 2-4 September 1995 in Kyoto, Japan. The wide-ranging topics examined included polymeric delivery systems for protein drugs, means of enhancement of protein drug transport, protein modification for improved pharmacokinetic/pharmacodynamic properties, targeting of peptide and protein drugs, and delivery of oligonucleotidcs and genes.
Introduction to the Series
Preface
List of Contributors
I. Peptide and Protein Drug Delivery
Peptide and Protein Drug Delivery: Past, Present and Future
Vincent H. L. Lee
II. Polymeric Delivery Systems for Peptide and Protein Drugs
Controlling Protein Diffusion in Hydrogels
Nicholas A. Peppas
Poly(ortho esters) for the Pulsed and Continuous Delivery of Peptides and Proteins
Jorge Heller, Ann-France Rime, Suchitra S. Rao, Bruce K. Fritzinger and Steve Y. Ng
New Delivery Systems for Recombinant Proteins—Practical Issues from Proof of Concept to Clinic
A. J. S. Jones, T. H. Nguyen, J. L. Cleland and R. Pearlman
III. Transport Enhancement of Peptide and Protein Drugs Across Selected Absorptive Barriers
Penetration Enhancement of Peptide Drugs: Palmitoyl Derivatives of Insulin and a Transition-state Mimic Tripeptide Inhibitor of HIV Protease as a Potential Anti-AIDS Drug for Oral Administration
Yoshiaki Kiso
Penetration Enhancement of Peptide and Protein Drugs by Electrochemical Means: Transdermal Iontophoresis
Michael J. Pikal
Technological and Development Issues of Iontophoretic Transport of Peptide and Protein Drugs
Burton H. Sage, Jr., C. Randolph Bock, John D. Denuzzio and Randal A. Hoke
Enhancement of Transferrin Receptor-medicated Transcytosis for Transepithelial Protein Delivery
Wei-Chiang Shen, Deven Shah, Mitchell E. Taub and Jiansheng Wan
Peptide Delivery across the Blood — Brain Barrier
Akira Tsuji
IV. Modification of Peptide and Protein Drugs for Improved Pharmacokinetic/Pharmacodynamic Properties
Improved Circulation Half-Life of Proteins Using Deletion Mutants
Tim J. Ahern
Pathophysiology of Reactive Oxygen Species: Analysis by Targeting SOD
Masayasu Inoue, Keiko Koyama and Mitsuru Hashida
V. Targeting of Peptide and Protein Drugs
Targeting: From Proteins to Genes
R. L. Juliano, Jeffery Hughes, Michael Fisher, Anna Avrutskaya, Yoko Shoji and Saghir Akhtar
(Protein)-Targeted Delivery with Particulate Systems
Daan J. A. Crommelin, James N. Herron and Gert Storm
Vascular Targeting as a New Approach to the Therapy of Solid Tumors: Validation in a Mouse Tumor Model
Philip E. Thrope and Francis J. Burrows
Recombinant DNA Vaccines: Use of Escherichia coli Envelop Proteins as Tools for Cellular and Molecular Targeting of Foreign Polypeptides in Bacteria and Protein Purification
J. M. Clément, C. Leclerc, R. Lo-Man, P. Martineau, A. Charbit, S. Szmelcman and M. Hofnung
Targeting of Proteins in the Brain following Release from a Polymer
Christine E. Krewson and W. Mark Saltzman
VI. Delivery of Oligonucleotides and Genes
Oligonucleotides as Potential Therapeutic Agents
Stanley T. Crooke
Liposomal DNA Delivery
Kyonghee Son and Leaf Huang
Gene Introduction into Animal Tissues
Mahito Nakanishi, Ken-ichi Ashihara, Takao Senda, Toru Kondo, Keiko Kato and Tadanori Mayumi
Systematic Delivery of Recombinant Proteins by Genetically Engineered Myoblasts
Jyotsna Dhawan and Helen M. Blau
Index
Biography
Vincent H, L, Lee is Gavin S. Herbert Professor and Chairman of the Department of Pharmaceutical Sciences in the School of Pharmacy of the University of Southern California, where he has taught since 1979. Mitsuru Hashida is Professor of Pharmaceutical and Drug Delivery Research in the Faculty of Pharmaceutical Sciences at Kyoto University, from where he received his 8.S., M.S. and Ph.D. degrees in 1974, 1976 and 1979 respectively. Yutaka Mizushima is a Professor of Medicine and Founding Director of the Institute of Medical Science at St. Marianna University.
