Translational Pain Research: From Mouse to Man

Lawrence Kruger, Alan R Light

September 12, 2017 by CRC Press
Reference - 456 Pages - 10 Color & 66 B/W Illustrations
ISBN 9781138116047 - CAT# K35456
Series: Frontiers in Neuroscience

USD$79.95

Add to Wish List
FREE Standard Shipping!

Features

    • Contains exciting new information derived from molecular biology, genetic studies, and gene expression studies in mice and humans
    • Presents recent advances in the development of basic science
    • Addresses the practical problems of clinical trials
    • Discusses pharmaceutical approaches to translational pain research
    • Includes new research findings on fibromyalgia, chronic fatigue, bone cancer, and osteoarthritis

    Summary

    One of the Most Rapidly Advancing Fields in Modern Neuroscience

    The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes.

    Distinguished Team of International Contributors

    In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on:

    • Nociceptor sensitization
    • Muscle nociceptors and metabolite detection
    • Visceral afferents in disease
    • Innovative rodent model for bone cancer pain
    • Highly specific receptor cloning
    • Modular molecular mechanisms relevant to painful neuropathies

    This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

    Share this Title