Transformation of Human Diploid Fibroblasts: Molecular and Genetic Mechanisms

1st Edition

George E. Milo, Bruce C. Casto

CRC Press
Published May 15, 1990
Reference - 304 Pages
ISBN 9780849349560 - CAT# 4956

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This comprehensive publication draws together the important aspects of carcinogen-cell interaction. This interesting work describes the regulation of normal cell proliferation, cellular responses to carcinogen damage, the biologic consequences of cellular DNA modification, the structural and genomic changes resulting from carcinogen insult, and the possible involvement of such changes in the conversion of normal human fibroblasts to malignant cells. It presents current reviews with up-to-date literature references and provides critical information from leading investigators that is essential in understanding the biology of human cell transformation. This volume is especially useful to advanced students in genetic toxicology, molecular biologists, and all who are interested in the molecular and macromolecular changes in human cells leading to neoplasia.


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