This volume is a comprehensive introduction to the analysis, binding, uptake, metabolism, kinetics, modeling, distribution, occurrence, toxicity and chelation of metals and fluoride in the body, with special reference to mineralized tissues. Both toxic and relatively harmless polyvalent cations and anions are considered. Included are some which are stable, and others which are radioactive. While a number are essential trace elements, others have no known metabolic role. Most chapters are concerned with the uptake of bone-seeking ions by the living skeleton, but aspects of the post-mortem uptake of metals and the process of fossilization are also considered. Highlighted are the utility of modern analytical techniques and the more important bone-seeking elements including aluminum, lead, cadmium, fluorine and the radioactive heavy metals including uranium and plutonium. This important publication is of particular value to those in the fields of biochemistry, radioactive waste, geology, physiology, dentistry, orthopedics, radiology and nuclear medicine, urology, industrial hygiene, pharmacology, anthropology, paleontology, and archeology.
Table of Contents
Introduction. Microanalytical Methods for the Localization of Trace Metals in Bone. The Detection of Radioactive Trace Elements in Bone Sections by Autoradiography. Aluminium Accumulation in Bone. The Distribution and Behavior of Metals in the Skeleton and Body: Studies with Radionuclides. The Metabolism and Effects of Fluoride. A History of Heavy Metal Contamination of Human Bones. Lead in Human Bones and Teeth. Cadmium in Human Bones and Teeth. Metabolism of Trace Metals in Animals (Non-Essential Pollutant Metals). Metabolism of Trace Metals in Animals (Essential Trace Elements). Interaction of Chelating Agents with Bone. The In Vitro Uptake of Trace Elements by Hydroxyapatite. Trace Metal Complexing Organic Molecules in Bone and Teeth. The Accumulation of Trace Metals in Bone During Fossilization. Index,