The increased incidence of pancreatic cancer in the Western world and its grave prognosis has resulted in an urgency for research in this area. Until now the available data on toxicology of the pancreas has been few and fragmentary, scattered throughout the literature. A benchmark volume, Toxicology of the Pancreas pulls together information in this neglected area of toxicological research and highlights fundamental research performed in the last ten years.
Leaders in the field discuss important structures, the detoxification and toxification process at the cellular and sub-cellular level, the distribution of phase 1 and phase 2 drug-metabolizing enzymes and their role in pancreatic disease, and the role of diet and toxicants on pancreatic disease. The book also covers the role of altered genes in the integrity of the pancreas and explores comparative toxicology in humans and in the lab species used in testing.
Illustrated with histological, electron microscopical, and immunohistochemical formats, this book provides a comprehensive and novel presentation of biological and toxicological data. It stands alone as a reliable resource of information easily accessible to professionals in different disciplines.
Table of Contents
Developmental Biology of the Vertebrate Pancreas, J.W. Lin and S.D. Leach
Gross Anatomy of the Pancreas, K. Yamaguchi, M. Kawamoto, and M. Tanaka
Fine Structure of the Pancreas, D.E. Bockman, T. Inagaki, and T. Morohoshi
Vascular Anatomy of the Pancreas, Y. Mikami, K. Takeda, T. Murakami, and S. Matsuno
Centroacinar Cells - A Neglected Essential Element of the Pancreas, P.M. Pour
Physiology of Exocrine Pancreas, W.Y. Chey, MD and T.-m. Chang, Ph.D.
Drug-Metabolizing Enzymes in the Human Pancreas. J. Standop, A. Ulrich, and P.M. Pour
Drug-Metabolizing Enzymes in the Pancreas of Animals, A. Ulrich and J. Standop
Pancreatic Exocrine-Endocrine Interaction, V. Liang W. Go, and Y. Wang
Nutritional Requirements of the Pancreas, D.S. Longnecker
Activity of Pancreatic Secretory Trypsin Inhibitor Is Essential against Pancreatotoxic Factors, M. Hirota
Pathological Perspectives of Pancreatic Mucins, M. Andrianifahanana, N. Moniaux, and S.K. Batra
Growth Factors in Pancreatic Diseases, A. Guweidhi, J. Kleeff, P. Pour, M.W. Büchler, and H. Friess
Toxicology of Natural Hormones and Hormonelike Chemicals, M.L. Steer, MD
Alcohol and Pancreatitis, S.L. Haas, A. Schneider, M.V. Singer
Chronic Pancreatitis: the Initial Tissue Damage and the Resulting Fibrosis Patterns, G. Klöppel
Chemically Induced Exocrine Degeneration, Atrophy, and Arterial Diseases in Rats, A. Nyska, A.E. Brix, M.P. Jokinen, D.M. Sells, M.E. Wyde, D. Orzech, J.K. Haseman, G. Flake, and N.J. Walker
Chronic Pancreatic Toxicity - Role of Stem Cells in the Conversion of Pancreas to Liver, M.S. Rao and J.K. Reddy
Environmental Factors and Exocrine Pancreatic Disease, A.B. Lowenfels, MD and P. Maisonneuve, Ing
Environmental Determinants of Exocrine Pancreatic Cancer, E.J. Duell, P.M. Bracci, and E.A. Holly
The Effects of Nutrients on Pancreatic Malignancy: Part II - Experimental Studies, P. Pour
Toxicity of Tobacco-Specific N-Nitrosamines, B. Prokopczyk, D. Hoffmann, and K. El-Bayoumy
Autoimmune Pancreatitis - Recent Concept, K. Okazaki
Role of Genetic Factors in Inflammatory Diseases of the Pancreas, F.U. Weiss and M.M. Lerch
Genetic Disorders Associated with Exocrine and Endocrine Pancreatic Tumors, H.T. Lynch, M.D. and C.A. Deters, R.N., J.F. Lynch, B.S.N., and R. Brand, M.D.
Cystic Fibrosis of the Pancreas - the Disease and Its Manifestations, A.P. Singh and S.K. Batra
Toxicology of the Endocrine Pancreas, M. Yalniz and P.M. Pour
Alterations of the Endocrine Pancreas, L. Rosenberg, M.D.
Pancreatic Cancer and Diabetes - Cellular Origin of Adeonocarcinoma, N. Moniaux, K.K. Pandey, P.M. Pour, and S.K. Batra