Topical Nail Products and Ungual Drug Delivery

S Narasimha Murthy, Howard I. Maibach

September 26, 2012 by CRC Press
Reference - 282 Pages - 37 Color & 74 B/W Illustrations
ISBN 9781439811290 - CAT# K10565


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  • Represents the seminal work on ungual and trans-ungual drug delivery
  • Overviews of the properties of the nail, its permeability, available formulations, and future concepts
  • Provides the most up-to-date information on ex vivo models of trans-ungual drug delivery
  • Covers ongoing research on physical and chemical techniques of drug permeation enhancement and novel techniques
  • Includes color and greyscale illustrations to show various diffusion cell models, ex vivo models, and procedures


Discussing existing techniques, ongoing research, new approaches, and basic concepts in the treatment of nail diseases, Topical Nail Products and Ungual Drug Delivery summarizes the current knowledge and represents a jumping-off point for creating novel techniques of drug delivery across the nail.

A growing area of pharmaceutical research, the search for efficient delivery techniques that can cross the nail barrier has yielded several effective strategies, brought together in this book.

Topics Include

  • Nail anatomy, physiology, diseases, and treatment
  • Permeability of the nail plate
  • Topical nail formulations
  • Approaches to enhance ungual and trans-ungual drug delivery
  • In vitro and in vivo models to evaluate topical nail formulations
  • Nail sampling techniques
  • Bioengineering of the nail
  • Trans-ungual iontophoresis
  • Pharmacokinetics of drugs in the nail apparatus
  • Onychopharmacokinetics: proposed model insight
  • Photodynamic therapy of nail diseases
  • The nail as a surrogate for investigating drug use