Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Second Edition

Ajay K. Banga

September 14, 2005 by CRC Press
Reference - 376 Pages - 12 B/W Illustrations
ISBN 9780849316302 - CAT# 1630

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  • Provides an understanding of protein formulation and delivery from the ground up
  • Includes information on FDA regulatory activities in peptide- and protein-based drug research, approval, and manufacturing
  • Explores peptide- and protein-based vaccines and therapeutic agents
  • Contains hard to find practical information on protein formulation
  • Discusses recent developments such as well-characterized biologicals, statistical design for protein preformulation, and process analytical technologies
  • Covers new developments in delivery systems, including a discussion of skin microporation and pulmonary delivery
  • Summary

    Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find up-to-date, relevant information on protein formulation and/or delivery systems and the need for a new edition is self-evident. This second edition continues the tradition of providing a ready-to-use reference of accurate information, tables, and illustrations.

    The book begins with the basics of the origin of recombinant proteins, explores structural and analytical aspects, and moves on to discuss the stability of proteins and peptides. Against this background, the author addresses preformulation and formulation considerations and provides detailed information on important topics such as lyophilization. He goes on to discuss various delivery systems, including controlled release delivery systems and products currently on the market. The book also contains newly added regulatory information and thoroughly investigates therapeutic drugs made from proteins as well as protein-based vaccines. A new chapter on recombinant protein subunit vaccines and their delivery systems has been added.

    The work of a single author, the book provides complex information in a simple, elegant, and cohesive style. The author minimizes overlap between coverage and includes extensive cross-referencing that links related topics. Completely revised and updated, packed with cutting-edge information, the second edition once again fills the need for a reference that pulls all the relevant information together into one resource.