This book provides a broad overview of all aspects of modern lymphokine research. It begins with the ways in which lymphokines play a role in the activation of the immune response and concludes with their participation in various facets of host defense. It devotes special attention to structure, mechanism of action, and range application. In addition, this fascinating work also shows how lymphokines are involved in other physiologic responses, such as reparative reactions involving fibrosis and angiogenesis. This is an excellent resource for students and investigators in the biomedical sciences, as well as clinicians who require up-to-date information about our current understanding of immune processes.
Table of Contents
Perspectives on Cell Mediated Immunity In Vivo. The Cytokine Concept: Historical Perspectives and Current Status of the Cloned Cytokines. T Cell Clones as Sources of Lymphokines. Receptors on T and B Lymphocytes. Intracellular and Extracellular Factors Promoting Lymphocyte Activation and Proliferation. Transmembrane Signaling in B Cell Activation. Lymphoid Growth Factors: Gene Regulation and Biochemical Mechanisms of Action. Interleukin 1 and its Biologically Related Cytokines. Interleukin 2. Cachectin (Tumor Necrosis Factor) and Lymphotoxin as Primary Mediators of Tissue Catabolism, Inflammation, and Shock. Production of Hemopoietic Colony Stimulating Factors. Lymphokines and Tumor Immunity. Lymphokines and Cytokines in Reparative Processes.