The nude, athymic mouse (nu/nu) has become generally accepted as a valuable tool to study the biology and therapy of human cancers. This volume presents a critical review of the scientific merits of the animal as a recipient of human tumor tissue transplants. Important information is provided regarding biology, immunology, and measures for genetic and microbiological control of the nude mouse. The discussion of transplantation sites and transplantability of human tumor tissue to the animals includes both the description of host factors and the tumor type involved. The characterization and monitoring of xenografts is followed by a review on their possible application for studies in tumor biology, such as hormones, growth factors, drug resistance, tumor markers, and heterogeneity. Experimental therapy is dedicated to cytostatic agents, hormones, monoclonal antibodies, cytokines, differentiation inducers and radiotherapy. The book also provides critical remarks regarding the limitation of the nude-mouse tumor models. The Nude Mouse in Oncology Research will provide essential reference information for oncology researchers, researchers who work with the nude mouse on a regular basis, and pharmaceutical companies.
Table of Contents
1. History and Pathology J�rgen Rygaard 2. Types of Immunodeficiency in Mice Simon P. Langdon and John F. Smyth 3. Breeding and Microbiological Control Tatsuji Nomura 4. Subcutaneous Xenografts J�rgen Rygaard 5. Tumorigenicity J.C. Romijn 6. Transplantability of Human Tumors �stein Fodstad 7. Alternative Sites of Tumor Development Epie Boven 8. Characterization and Monitoring Epie Boven 9. Studies in Tumor Cell Biology Simon P. Langdon and John F. Smyth 10. Metastatic Models Raffaella Giavazzi 11. Experimental Therapy in Subcutaneous Transplants David P. Houchens and Artemio A. Ovejera 12. Radiotherapy Einar K. Rofstad 13. Conventional Chemotherapy D.P. Berger, B.R. Winterhalter, and H.H. Fiebig 14. Analogs of Conventional Agents Epie Boven 15. Investigational Agents Ghanem Atassi 16. Hormones G.J. van Steenbrugge 17. Monoclonal Antibodies Hidde J. Haisma 18. Cytokines S.T.A. Malik and F.R. Balkwill 19. Differentiation Inducers Guus A.M.S. van Dongen and Boudewijn J.M. Braakhuis 20. Limitations for Studies in Human Tumor Biology �stein Fodstad 21. Limi tations for Treatment Studies Boudewijn J.M et al 22. New Drug Development Benjamin Winograd 23. Preclinical Phase II Trials H.H. Fiebig and D.P. Berger