A synthesis and collation of the recent material regarding the role of the neutrophil in basic pathological processes is presented in this volume. The mechanisms of chemotaxis, secretion, phagocytosis, intracellular killing, oxygen radical production and arachidonate production are comprehensively reviewed. Stimulus response coupling in the neutrophil, with chapters on intracellular Ca2+, C-Kinase, phospholipid metabolism, microfilaments and membrane electrophysiology are extensively discussed. Each chapter provides a critical review by experts with over 1,000 cited references. Invaluable to graduate students and medical and scientific researchers, this book provides a unique, up-to-date account of cellular biochemistry and physiology of the neutrophil.
Table of Contents
1. The Significance of Stimulus-Response Coupling in the Neutrophil for Physiology and Pathology 2. Characteristics and Mechanisms of Secretion by Neutrophils 3. Biophysics of Leukocytes: Neutrophil Chemotaxis; Characteristics and Mechanisms 4. The Molecular Mechanism of Oxygen Reduction by the Neutrophil Oxidase 5. Mobilization, Metabolism, and Bio-logical Effects of Eicosanoids in Polymorphonuclear Leuko-cytes 6. The Cortical Actin Filament Network of Neutrophil Leukocytes during Phagocytosis and Chemotaxis 7. The Role of Inositol Phospholipid Metabolism and Diacylglycerol Production in Neutrophil Signal Transduction 8. Role of Calcium in Neutrophil Activation 9. Ca2+-Dependent and Independent Mechanisms in Neutrophil Activation; Roles of Kinase-C, Diacyl-glycerol, and Unidentified Intracellular Messengers 10. Ion Transport in Phagocytes