The Human Complement System in Health and Disease

1st Edition

John E. Volanakis

CRC Press
Published February 25, 1998
Reference - 672 Pages
ISBN 9780824798987 - CAT# DK5530

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Summary

This authoritative, single-source reference provides comprehensive examinations of the complement system-offering recent findings in basic science on the structure, biology, physiology, and pathophysiology of complement proteins and the latest therapeutic approaches towards the control of complement-mediated diseases.
Written by over 40 international experts from North America, Europe, and Asia, The Human Complement System in Health and Disease
  • describes the molecular architecture of the complement system
  • details the structure of complement genes
  • discusses gene organization as well as the topology and chemistry of ligand-binding sites and catalytic centers of complement proteins
  • analyzes complement organization and activation, including phylogeny and the newly discovered lectin pathway
  • elucidates the regulation of complement gene expression and the structure and function of bioactive peptides
  • explicates opsonic and immunoregulatory properties of complement fragments, endothelial responses, and interactions with viruses and bacteria
  • and more!
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