This book provides the first comprehensive review of research that addresses the immunomodulation of gastrointestinal motility. Results from this new field of research are important for understanding motility disturbances and symptom-generation in a variety of clinical gastroenterological problems, including ulcerative colitis, Crohn's disease, enteric infections, and food allergies. The book provides overviews on current perspectives regarding the nature of inflammatory processes, inflammatory mediators, and other immune factors. It also describes a variety of experimental approaches that have been used to study the interactions between immune cells and smooth muscle or enteric nerves. The approaches include in vivo, as well as in vitro studies. Researchers involved in the general field of immunophysiology, as well as the more specific fields of gastrointestinal motility and inflammatory bowel diseases will find this book to be invaluable in their research.
Table of Contents
Preface (Stephen M. Collins, William J. Snape, Jr.). Acute and Chronic Inflammation (Jack Gauldie). Healing and Repair (Robert Riddell). Cholesterol Feeding and Gallbladder Muscle Contractility (Norman Weisbrodt, Young Fang Li, Frank G. Moody, Diane Haley-Russell, Stuart I. Myers). Inflammation Alters Smooth Muscle Function in the Gut: Studies on the Nematode-Infected Rat (Stephen M. Collins, D.L. Vermillion, J.D. Huizinga, M.J. Muller). Specific Effect of Infection and Malnutrition on Intestinal Longitudinal Smooth Muscle Response in Yersinia Enterocolitica in the Rabbit (Brent Scott). In-Vivo Colonic Motility and Transit in Ulcerative Colitis (S. Narasimha Reddy, Gabriele Bazzocchi, Simon Chan, Kathy Akashi, Javier Villanueva-Meyer, George Yanni, Ismael Mena, William J. Snape, Jr.). Effect of Mucosal Inflammation on Colonic Smooth Muscle Contraction. (Y.N. Xie, W. Gerthoffer, S.N. Reddy, V.E. Eysselein, F. Cominelli, W.J. Snape, Jr.). In Vivo Motor Response to Gut Inflammation (Sushil K. Sarna, Mary F. Otterson, Verne E. Cowles, Ashwani K. Sethi, Gordon L. Telford). An Investigation In Vitro of the Properties of the Individual Muscle Layers of the Rabbit Colon in an Induced Colitis (W.H. Percy, M.B. Burton, Y. Jacobowitx, R. Burakoff). Smooth Muscle Function in Inflammatory Bowel Disease (Jan D. Huizinga, Dianne L. Vermillion, Carla Cuthbert, Stephen M. Collins). Collagen Production by the Intestinal Smooth Muscle Cell in Response to Inflammation: Wound Healing in the Gut (Martin P. Graham). Smooth Muscle Growth in the Inflamed Intestine of the Rat (M.G. Blennerhassett, S.M. Collins). Ultrastructure of Human Gastrointestinal System. Interactions Among Mast Cells, Eosinophils, Nerves and Muscle in Human Disease (Ann M. Dvorak). Gut Neuropeptides and the Pathophysiology of Inflammatory Bowel Diseases (Timothy R. Koch, Ammon Sonnenberg, J. Aidan Carney). Immunomodulation of Electrical and Synaptic Behavior of Myenteric Neurons of Guinea Pig Small Intestine During Infection with Trichinella Spiralis (Jeffrey M. Palmer). Visceral Afferent Innervation and Inflammation (Helen E. Raybould, Emeran Mayer). Intestinal Inflammation in the Parasitized Host (Gilbert A. Castro). Strategies for Elucidating Immunological Mechanisms in Intestinal Smooth Muscle Pathophysiology (Dean Befus). Mast Cell and Muscle Interactions in Animals and Man (Dianne L. Vermillion, Stephen M. Collins, Jan Huizinga). The Effect of Activated Inflammatory Cells on Colonic Smooth Muscle Contraction (Lin Chang, Martha Hierro, Louise LeDuc, Fergus Shanahan, Fabio Cominelli, William J. Snape, Jr.). Lymphocyte Interactions With Smooth Muscle Cells and Nerves (K. Geboes, P. Rutgeerts, V. Desmet). Inflammatory Mediators and Gastrointestinal Motility (John L. Wallace, Nancy I.A. Byles, R. Brent Scott). Putative Mediators in Inflammatory Bowel Disease: Substance P and Calcitonin Gene-Related Peptide (Viktor E. Eysselein, Catia Sternini, Fabio Cominelli, Cynthia C. Nast). The Role of Granulocyte-Derived Oxidants in Intestinal Mucosal Injury (Tamaki Yamada, Matthew B. Grisham). Role of Interleukin-1 in Experimental Colitis (Fabio Cominelli). Intestinal Muscle Effects of Clostridium Difficile Toxins (Richard J. Gilbert). Ischemia-Reperfusion: A Model of Acute Intestinal Inflammation (Barbara J. Zimmerman, Paul Kubes, D. Neil Granger). Intestinal Effects of Bacterial Chemotactic Peptides: Induction of Inflammation, Release of Eicosanoids (Louise E. LeDuc, Cynthia C. Nast, Fergus Shanahan, Alda Vidrich). Idiopathic Colitis and Colon Cancer in the Cotton-Top Tamarin (J.D. Wood, O.C. Peck). Modulation of Gallbladder Contraction by the Oxidant Monochloramine (T.S. Gaginella, C. Moummi, G.W. Gullikson). c. 376 pp., 7x10, 29 tables, due November 1990, ISBN 0-8493-0174-2.